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Comprehensive serological profiling of human populations using a synthetic human virome

Overview of attention for article published in Science, June 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Readers on

mendeley
221 Mendeley
citeulike
8 CiteULike
Title
Comprehensive serological profiling of human populations using a synthetic human virome
Published in
Science, June 2015
DOI 10.1126/science.aaa0698
Pubmed ID
Authors

George J. Xu, Tomasz Kula, Qikai Xu, Mamie Z. Li, Suzanne D. Vernon, Thumbi Ndung’u, Kiat Ruxrungtham, Jorge Sanchez, Christian Brander, Raymond T. Chung, Kevin C. O’Connor, Bruce Walker, H. Benjamin Larman, Stephen J. Elledge

Abstract

The human virome plays important roles in health and immunity. However, current methods for detecting viral infections and antiviral responses have limited throughput and coverage. Here, we present VirScan, a high-throughput method to comprehensively analyze antiviral antibodies using immunoprecipitation and massively parallel DNA sequencing of a bacteriophage library displaying proteome-wide peptides from all human viruses. We assayed over 10(8) antibody-peptide interactions in 569 humans across four continents, nearly doubling the number of previously established viral epitopes. We detected antibodies to an average of 10 viral species per person and 84 species in at least two individuals. Although rates of specific virus exposure were heterogeneous across populations, antibody responses targeted strongly conserved "public epitopes" for each virus, suggesting that they may elicit highly similar antibodies. VirScan is a powerful approach for studying interactions between the virome and the immune system.

Twitter Demographics

The data shown below were collected from the profiles of 496 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 221 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 12 5%
Japan 5 2%
Germany 2 <1%
France 2 <1%
Israel 2 <1%
Netherlands 2 <1%
Switzerland 2 <1%
United Kingdom 2 <1%
Luxembourg 1 <1%
Other 4 2%
Unknown 187 85%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 67 30%
Researcher 64 29%
Professor > Associate Professor 16 7%
Other 15 7%
Student > Master 14 6%
Other 45 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 121 55%
Medicine and Dentistry 28 13%
Biochemistry, Genetics and Molecular Biology 15 7%
Unspecified 10 5%
Immunology and Microbiology 9 4%
Other 38 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 967. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2017.
All research outputs
#2,150
of 8,658,756 outputs
Outputs from Science
#121
of 42,581 outputs
Outputs of similar age
#61
of 222,869 outputs
Outputs of similar age from Science
#6
of 766 outputs
Altmetric has tracked 8,658,756 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 42,581 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,869 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 766 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.