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Mendeley readers
Attention Score in Context
| Title |
Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling
|
|---|---|
| Published in |
Nature Communications, April 2018
|
| DOI | 10.1038/s41467-018-03801-z |
| Pubmed ID | |
| Authors |
Dongyang Cheng, Xiaoli Yan, Guofu Qiu, Juan Zhang, Hanwei Wang, Tingting Feng, Yarong Tian, Haiping Xu, Meiqing Wang, Wanzhong He, Ping Wu, Randall B Widelitz, Cheng-Ming Chuong, Zhicao Yue |
| Abstract |
Branching morphogenesis is a general mechanism that increases the surface area of an organ. In chicken feathers, the flat epithelial sheath at the base of the follicle is transformed into periodic branches. How exactly the keratinocytes are organized into this pattern remains unclear. Here we show that in the feather follicle, the pre-branch basal keratinocytes have extensive filopodia, which contract and smooth out after branching. Manipulating the filopodia via small GTPases RhoA/Cdc42 also regulates branch formation. These basal filopodia help interpret the proximal-distal FGF gradient in the follicle. Furthermore, the topological arrangement of cell adhesion via E-Cadherin re-distribution controls the branching process. Periodic activation of Notch signaling drives the differential cell adhesion and contraction of basal filopodia, which occurs only below an FGF signaling threshold. Our results suggest a coordinated adjustment of cell shape and adhesion orchestrates feather branching, which is regulated by Notch and FGF signaling. |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 23% |
| Researcher | 3 | 14% |
| Student > Doctoral Student | 2 | 9% |
| Student > Bachelor | 2 | 9% |
| Professor > Associate Professor | 2 | 9% |
| Other | 3 | 14% |
| Unknown | 5 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 32% |
| Agricultural and Biological Sciences | 5 | 23% |
| Medicine and Dentistry | 2 | 9% |
| Computer Science | 1 | 5% |
| Arts and Humanities | 1 | 5% |
| Other | 2 | 9% |
| Unknown | 4 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2018.
All research outputs
#5,817,224
of 23,047,237 outputs
Outputs from Nature Communications
#33,834
of 47,484 outputs
Outputs of similar age
#101,469
of 329,293 outputs
Outputs of similar age from Nature Communications
#920
of 1,203 outputs
Altmetric has tracked 23,047,237 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 47,484 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,293 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 1,203 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.