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Vaccines for preventing invasive salmonella infections in people with sickle cell disease

Overview of attention for article published in Cochrane database of systematic reviews, June 2015
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Title
Vaccines for preventing invasive salmonella infections in people with sickle cell disease
Published in
Cochrane database of systematic reviews, June 2015
DOI 10.1002/14651858.cd006975.pub3
Pubmed ID
Authors

Friday Odey, Uduak Okomo, Angela Oyo-Ita

Abstract

Salmonella infections are a common bacterial cause of invasive disease in people with sickle cell disease especially children, and are associated with high morbidity and mortality rates. Although available in some centres, people with sickle cell anaemia are not routinely immunized with salmonella vaccines. This is an update of a previously published Cochrane Review. To determine whether routine administration of salmonella vaccines to people with sickle cell disease reduces the morbidity and mortality associated with infection. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.We also conducted a search of the LILACS database.Date of most recent searches: 05 May 2015. We planned to select all randomized controlled trials that compared the use of either the inactivated vaccine or an oral attenuated vaccine with a placebo among people with sickle cell disease. Equally, studies that compared the efficacy of one vaccine type over another were to be selected for the review. No trials of salmonella vaccines in people with sickle cell disease were found. There is an absence of randomized controlled trial evidence relating to the scope of this review. It is expected that salmonella vaccines may be useful in people with sickle cell disease, especially in resource-poor settings where the majority of those who suffer from the condition are found. Unfortunately, there are no randomized controlled trials on the efficacy and safety of the different types of salmonella vaccines in people with sickle cell disease. We conclude that there is a need for a well-designed, adequately-powered, randomized controlled trial to assess the benefits and risks of the different types of salmonella vaccines as a means of improving survival and decreasing mortality from salmonella infections in people with sickle cell disease.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 17%
Student > Master 3 10%
Researcher 3 10%
Student > Doctoral Student 3 10%
Student > Bachelor 3 10%
Other 7 24%
Unknown 5 17%
Readers by discipline Count As %
Medicine and Dentistry 11 38%
Agricultural and Biological Sciences 4 14%
Nursing and Health Professions 2 7%
Mathematics 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 3 10%
Unknown 7 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2016.
All research outputs
#10,024,051
of 12,527,219 outputs
Outputs from Cochrane database of systematic reviews
#8,725
of 8,923 outputs
Outputs of similar age
#161,812
of 234,348 outputs
Outputs of similar age from Cochrane database of systematic reviews
#219
of 235 outputs
Altmetric has tracked 12,527,219 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 235 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.