Title |
Cancer therapy and cardiovascular risk: focus on bevacizumab
|
---|---|
Published in |
Cancer Management and Research, June 2015
|
DOI | 10.2147/cmar.s77400 |
Pubmed ID | |
Authors |
Panagiota Economopoulou, Athanasios Kotsakis, Ioannis Kapiris, Nikolaos Kentepozidis |
Abstract |
Recognition and management of treatment-related cardiovascular toxicity, defined as either an acute cardiac event or a chronic condition, has been tightly integrated into routine cancer care and has become an important component in treatment selection. Several chemotherapeutic agents, such as anthracyclines, are traditionally characterized as cardiotoxic, but cardiovascular adverse events are also associated with commonly used molecular targeted therapies. In the past decade, bevacizumab, a monoclonal humanized antibody against vascular endothelial growth factor, has been introduced in the treatment of a variety of metastatic malignancies. Despite its efficacy, bevacizumab has been associated with significant risk of cardiovascular complications, such as hypertension, cardiac ischemia, and congestive heart failure. This review will focus on the cardiovascular toxicity of bevacizumab, providing the latest evidence on the incidence, clinical spectrum, risk factors, and responsible mechanisms. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 33% |
Canada | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 1% |
Unknown | 77 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 14% |
Student > Bachelor | 9 | 12% |
Student > Postgraduate | 8 | 10% |
Student > Master | 6 | 8% |
Student > Doctoral Student | 5 | 6% |
Other | 15 | 19% |
Unknown | 24 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 36% |
Biochemistry, Genetics and Molecular Biology | 6 | 8% |
Agricultural and Biological Sciences | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Mathematics | 1 | 1% |
Other | 4 | 5% |
Unknown | 31 | 40% |