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Hair growth effect of minoxidil

Overview of attention for article published in Folia Pharmacologica Japonica, January 2002
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)

Mentioned by

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1 Wikipedia page
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1 video uploader

Citations

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21 Dimensions

Readers on

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17 Mendeley
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Title
Hair growth effect of minoxidil
Published in
Folia Pharmacologica Japonica, January 2002
DOI 10.1254/fpj.119.167
Pubmed ID
Authors

Susumu OTOMO

Abstract

The length and size of hair are depend on the anagen term in its hair cycle. It has been reported that the some cell growth factors, such as VEGF, FGF-5S, IGF-1 and KGF, induce the proliferation of cells in the matrix, dermal papilla and dermal papillary vascular system and increase the amount of extra cellular matrix in dermal papilla and then maintain follicles in the anagen phase. On the other hand, negative factors, like FGF-5, thrombospondin, or still unknown ones, terminate the anagen phase. If the negative factors become dominant against cell proliferation factors according to fulfilling some time set by the biological clock for hair follicles, TGF beta induced in the matrix tissues evokes apoptosis of matrix cells and shifts the follicles from anagen to catagen. Androgenetic alopecia is caused by miniaturizing of hair follicles located in the frontal or crown part of scalp and are hereditarily more sensitive to androgen. In their hair cycles, the androgen shortens the anagen phase of follicles and shifts them to the catagen phase earlier than usual. The mode of action of hair growth effect of minoxidil is not completely elucidated, but the most plausible explanation proposed here is that minoxidil works as a sulfonylurea receptor (SUR) activator and prolongs the anagen phase of hair follicles in the following manner: minoxidil (1) induces cell growth factors such as VEGF, HGF, IGF-1 and potentiates HGF and IGF-1 actions by the activation of uncoupled SUR on the plasma membrane of dermal papilla cells, (2) inhibits of TGF beta induced apoptosis of hair matrix cells by opening the Kir 6.0 channel pore coupled with SUR on the mitochondrial inner membrane, and (3) dilates hair follicle arteries and increases blood flow in dermal papilla by opening the Kir 6.0 channel pore coupled with SUR on the plasma membrane of vascular smooth muscle cells.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 6%
Italy 1 6%
Germany 1 6%
Unknown 14 82%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 24%
Other 3 18%
Student > Ph. D. Student 2 12%
Researcher 2 12%
Student > Doctoral Student 1 6%
Other 2 12%
Unknown 3 18%
Readers by discipline Count As %
Medicine and Dentistry 7 41%
Immunology and Microbiology 2 12%
Agricultural and Biological Sciences 2 12%
Pharmacology, Toxicology and Pharmaceutical Science 2 12%
Economics, Econometrics and Finance 1 6%
Other 0 0%
Unknown 3 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2021.
All research outputs
#5,510,827
of 17,595,144 outputs
Outputs from Folia Pharmacologica Japonica
#139
of 646 outputs
Outputs of similar age
#75,637
of 242,453 outputs
Outputs of similar age from Folia Pharmacologica Japonica
#1
of 1 outputs
Altmetric has tracked 17,595,144 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 646 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,453 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them