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Analysis of angiogenic markers in oral squamous cell carcinoma-gene and protein expression

Overview of attention for article published in Head & Face Medicine, June 2015
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About this Attention Score

  • Among the highest-scoring outputs from this source (#31 of 175)
  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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2 tweeters
facebook
1 Facebook page

Citations

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4 Dimensions

Readers on

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22 Mendeley
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Title
Analysis of angiogenic markers in oral squamous cell carcinoma-gene and protein expression
Published in
Head & Face Medicine, June 2015
DOI 10.1186/s13005-015-0076-7
Pubmed ID
Authors

Susanne Jung, Sonja Sielker, Nikolai Purcz, Christoph Sproll, Yahya Acil, Johannes Kleinheinz

Abstract

Therapeutic strategies attacking oral squamous cell carcinoma have not essentially succeeded to improve long-term prognosis and overall survival over the last decades. Therefore, in this study, we aimed to illuminate the molecular regulation of angiogenesis in this tumour entity in order to demask novel markers of prognosis or therapeutic approach. A panel of significant transcriptional alterations in angiogenic genes of 83 cancer samples was established by comparison to 30 samples of healthy oral mucosa with microarray technique. Immunohistochemistry (IHC) was performed to trace the signalling cascade from gene to protein level. A distinctive expression profile of VEGFA, EFNB2, PECAM1/CD31, ANGPT1 and ANGPT2 was revealed: VEGFA, EFNB2, and ANGPT2 were found overexpressed in 84 % to 95 % of tumour samples. In contrast, the expression of CD31 and ANGPT1 was downregulated in 80 % to 95 % of tumour samples. IHC confirmed results of the microarray analysis. Tumours with lymphatic spread showed higher gene expression rates of VEGFA, EFNB2 and ANGPT2 in moderately differentiated tumours and of VEGFA and EFNB2 in small tumours, respectively. The ANGPT1/ ANGPT2 transcription ratio was found decreased in larger tumours and especially in tumours without lymphatic spread. A characteristic expression profile of angiogenic markers was established. The specific overexpression of EFNB2 in small tumours with lymphatic spread and the typical decrease of the ANGPT1/ ANGPT2 ratio in larger tumours give weight to EFNB2 and angiopoietins as prognostic factors and potential therapeutic targets.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 5%
Germany 1 5%
Unknown 20 91%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 23%
Researcher 3 14%
Student > Ph. D. Student 3 14%
Student > Bachelor 2 9%
Other 2 9%
Other 3 14%
Unknown 4 18%
Readers by discipline Count As %
Medicine and Dentistry 8 36%
Agricultural and Biological Sciences 7 32%
Biochemistry, Genetics and Molecular Biology 2 9%
Unknown 5 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2015.
All research outputs
#2,341,178
of 5,263,645 outputs
Outputs from Head & Face Medicine
#31
of 175 outputs
Outputs of similar age
#78,479
of 177,904 outputs
Outputs of similar age from Head & Face Medicine
#3
of 9 outputs
Altmetric has tracked 5,263,645 research outputs across all sources so far. This one has received more attention than most of these and is in the 54th percentile.
So far Altmetric has tracked 175 research outputs from this source. They receive a mean Attention Score of 1.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,904 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.