Title |
Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas
|
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Published in |
Angewandte Chemie. International Edition, June 2015
|
DOI | 10.1002/anie.201502677 |
Pubmed ID | |
Authors |
Guang Yang, Miriam O'Duill, Véronique Gouverneur, Marie Pierre Krafft |
Abstract |
Perfluorohexane gas when introduced in the air atmosphere above a film of phospholipid self-supported on an aqueous solution of C2 F5 -labeled compounds causes the recruitment and immobilization of the latter in the interfacial film. When the phospholipid forms a liquid-condensed Gibbs monolayer, which is the case for dipalmitoylphosphatidylcholine (DPPC), the C2 F5 -labeled molecule remains trapped in the monolayer after removal of F-hexane. Investigations involve bubble profile analysis tensiometry (Gibbs films), Langmuir monolayers and microbubble experiments. The new phenomenon was utilized to incorporate a hypoxia biomarker, a C2 F5 -labeled nitrosoimidazole (EF5), in microbubble shells. This finding opens perspectives in the delivery of fluorinated therapeutic molecules and biomarkers. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Germany | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | 4% |
Unknown | 22 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 17% |
Student > Ph. D. Student | 4 | 17% |
Student > Master | 3 | 13% |
Professor > Associate Professor | 2 | 9% |
Other | 1 | 4% |
Other | 2 | 9% |
Unknown | 7 | 30% |
Readers by discipline | Count | As % |
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Chemistry | 7 | 30% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
Engineering | 2 | 9% |
Physics and Astronomy | 1 | 4% |
Environmental Science | 1 | 4% |
Other | 2 | 9% |
Unknown | 8 | 35% |