Title |
Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
|
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Published in |
International Journal of Nanomedicine, June 2015
|
DOI | 10.2147/ijn.s80349 |
Pubmed ID | |
Authors |
Jessica Swanner, Jade Mims, David L Carroll, Steven A Akman, Cristina M Furdui, Suzy V Torti, Ravi N Singh |
Abstract |
Identification of differential sensitivity of cancer cells as compared to normal cells has the potential to reveal a therapeutic window for the use of silver nanoparticles (AgNPs) as a therapeutic agent for cancer therapy. Exposure to AgNPs is known to cause dose-dependent toxicities, including induction of oxidative stress and DNA damage, which can lead to cell death. Triple-negative breast cancer (TNBC) subtypes are more vulnerable to agents that cause oxidative stress and DNA damage than are other breast cancer subtypes. We hypothesized that TNBC may be susceptible to AgNP cytotoxicity, a potential vulnerability that could be exploited for the development of new therapeutic agents. We show that AgNPs are highly cytotoxic toward TNBC cells at doses that have little effect on nontumorigenic breast cells or cells derived from liver, kidney, and monocyte lineages. AgNPs induced more DNA and oxidative damage in TNBC cells than in other breast cells. In vitro and in vivo studies showed that AgNPs reduce TNBC growth and improve radiation therapy. These studies show that unmodified AgNPs act as a self-therapeutic agent with a combination of selective cytotoxicity and radiation dose-enhancement effects in TNBC at doses that are nontoxic to noncancerous breast and other cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Korea, Republic of | 1 | 1% |
Mexico | 1 | 1% |
Germany | 1 | 1% |
Unknown | 95 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 24% |
Student > Master | 14 | 14% |
Researcher | 11 | 11% |
Student > Bachelor | 7 | 7% |
Student > Postgraduate | 5 | 5% |
Other | 12 | 12% |
Unknown | 26 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 16 | 16% |
Chemistry | 11 | 11% |
Medicine and Dentistry | 10 | 10% |
Agricultural and Biological Sciences | 6 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Other | 17 | 17% |
Unknown | 35 | 35% |