Title |
Systemic autoimmune disease in asbestosis rapidly responding to anti-interleukin-1beta antibody canakinumab: a case report
|
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Published in |
BMC Musculoskeletal Disorders, June 2015
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DOI | 10.1186/s12891-015-0602-6 |
Pubmed ID | |
Authors |
Laura Niccoli, Emanuele Cassarà, Olga Kaloudi, Carlotta Nannini, Micaela Romagnoli, Fabrizio Cantini |
Abstract |
Asbestosis is characterized by lung and pleural fibrosis and by immune system dysregulation, with autoantibody production and systemic immune-mediated disease. No specific therapies are available for asbestosis. Recently, the pivotal pathogenic role exerted by interleukin-1beta has been recently reported. We treated with anti-interleukin 1 beta targeted antibody canakinumab a 67 year old man with asbestosis and long lasting systemic autoimmune features. A dramatic improvement in clinical manifestations was observed at 1 week after the first injection, with complete clinical remission at 4 months. This case suggests new perspectives for the treatment of asbestosis and its systemic features. |
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United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Librarian | 1 | 7% |
Student > Bachelor | 1 | 7% |
Student > Ph. D. Student | 1 | 7% |
Student > Master | 1 | 7% |
Professor > Associate Professor | 1 | 7% |
Other | 1 | 7% |
Unknown | 9 | 60% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 3 | 20% |
Nursing and Health Professions | 2 | 13% |
Computer Science | 1 | 7% |
Unknown | 9 | 60% |