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Integrated web visualizations for protein-protein interaction databases

Overview of attention for article published in BMC Bioinformatics, June 2015
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  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Average Attention Score compared to outputs of the same age and source

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7 X users
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2 Facebook pages

Citations

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55 Dimensions

Readers on

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106 Mendeley
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8 CiteULike
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Title
Integrated web visualizations for protein-protein interaction databases
Published in
BMC Bioinformatics, June 2015
DOI 10.1186/s12859-015-0615-z
Pubmed ID
Authors

Fleur Jeanquartier, Claire Jean-Quartier, Andreas Holzinger

Abstract

Understanding living systems is crucial for curing diseases. To achieve this task we have to understand biological networks based on protein-protein interactions. Bioinformatics has come up with a great amount of databases and tools that support analysts in exploring protein-protein interactions on an integrated level for knowledge discovery. They provide predictions and correlations, indicate possibilities for future experimental research and fill the gaps to complete the picture of biochemical processes. There are numerous and huge databases of protein-protein interactions used to gain insights into answering some of the many questions of systems biology. Many computational resources integrate interaction data with additional information on molecular background. However, the vast number of diverse Bioinformatics resources poses an obstacle to the goal of understanding. We present a survey of databases that enable the visual analysis of protein networks. We selected M =10 out of N =53 resources supporting visualization, and we tested against the following set of criteria: interoperability, data integration, quantity of possible interactions, data visualization quality and data coverage. The study reveals differences in usability, visualization features and quality as well as the quantity of interactions. StringDB is the recommended first choice. CPDB presents a comprehensive dataset and IntAct lets the user change the network layout. A comprehensive comparison table is available via web. The supplementary table can be accessed on http://tinyurl.com/PPI-DB-Comparison-2015 . Only some web resources featuring graph visualization can be successfully applied to interactive visual analysis of protein-protein interaction. Study results underline the necessity for further enhancements of visualization integration in biochemical analysis tools. Identified challenges are data comprehensiveness, confidence, interactive feature and visualization maturing.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 3%
Germany 2 2%
India 2 2%
Austria 2 2%
Korea, Republic of 1 <1%
Italy 1 <1%
Spain 1 <1%
Unknown 94 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 22%
Researcher 20 19%
Student > Master 16 15%
Student > Bachelor 11 10%
Professor > Associate Professor 6 6%
Other 15 14%
Unknown 15 14%
Readers by discipline Count As %
Computer Science 28 26%
Biochemistry, Genetics and Molecular Biology 21 20%
Agricultural and Biological Sciences 21 20%
Chemistry 4 4%
Nursing and Health Professions 2 2%
Other 7 7%
Unknown 23 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2015.
All research outputs
#7,216,867
of 22,813,792 outputs
Outputs from BMC Bioinformatics
#2,863
of 7,284 outputs
Outputs of similar age
#77,642
of 239,955 outputs
Outputs of similar age from BMC Bioinformatics
#55
of 112 outputs
Altmetric has tracked 22,813,792 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 7,284 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,955 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.