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Mendeley readers
Attention Score in Context
| Title |
Stem cell derived in vivo -like human cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging
|
|---|---|
| Published in |
Lab on a Chip - Miniaturisation for Chemistry & Biology, January 2015
|
| DOI | 10.1039/c5lc00449g |
| Pubmed ID | |
| Authors |
Gunnar Bergström, Jonas Christoffersson, Kristin Schwanke, Robert Zweigerdt, Carl-Fredrik Mandenius |
| Abstract |
Beating in vivo-like human cardiac bodies (CBs) were used in a microfluidic device for testing cardiotoxicity. The CBs, cardiomyocyte cell clusters derived from induced pluripotent stem cells, exhibited typical structural and functional properties of the native human myocardium. The CBs were captured in niches along a perfusion channel in the device. Video imaging was utilized for automatic monitoring of the beating frequency of each individual CB. The device allowed assessment of cardiotoxic effects of drug substances doxorubicin, verapamil and quinidine on the 3D clustered cardiomyocytes. Beating frequency data recorded over a period of 6 hours are presented and compared to literature data. The results indicate that this microfluidic setup with imaging of CB characteristics provides a new opportunity for label-free, non-invasive investigation of toxic effects in a 3D microenvironment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Austria | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 85 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 24% |
| Student > Master | 16 | 18% |
| Student > Bachelor | 15 | 17% |
| Researcher | 13 | 15% |
| Professor > Associate Professor | 4 | 5% |
| Other | 10 | 11% |
| Unknown | 9 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 20% |
| Biochemistry, Genetics and Molecular Biology | 16 | 18% |
| Engineering | 14 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
| Medicine and Dentistry | 6 | 7% |
| Other | 15 | 17% |
| Unknown | 13 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2015.
All research outputs
#23,109,385
of 25,756,911 outputs
Outputs from Lab on a Chip - Miniaturisation for Chemistry & Biology
#5,387
of 5,997 outputs
Outputs of similar age
#308,877
of 361,654 outputs
Outputs of similar age from Lab on a Chip - Miniaturisation for Chemistry & Biology
#394
of 505 outputs
Altmetric has tracked 25,756,911 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,997 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,654 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 505 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.