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Stem cell derived in vivo-like human cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging

Overview of attention for article published in Lab on a Chip - Miniaturisation for Chemistry & Biology, June 2015
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Title
Stem cell derived in vivo-like human cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging
Published in
Lab on a Chip - Miniaturisation for Chemistry & Biology, June 2015
DOI 10.1039/c5lc00449g
Pubmed ID
Authors

Gunnar Bergström, Jonas Christoffersson, Kristin Schwanke, Robert Zweigert, Carl-Fredrik Mandenius, Robert Zweigerdt

Abstract

Beating in vivo-like human cardiac bodies (CBs) were used in a microfluidic device for testing cardiotoxicity. The CBs, cardiomyocyte cell clusters derived from induced pluripotent stem cells, exhibited typical structural and functional properties of the native human myocardium. The CBs were captured in niches along a perfusion channel in the device. Video imaging was utilized for automatic monitoring of the beating frequency of each individual CB. The device allowed assessment of cardiotoxic effects of drug substances doxorubicin, verapamil and quinidine on the 3D clustered cardiomyocytes. Beating frequency data recorded over a period of 6 hours are presented and compared to literature data. The results indicate that this microfluidic setup with imaging of CB characteristics provides a new opportunity for label-free, non-invasive investigation of toxic effects in a 3D microenvironment.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 2%
Japan 1 2%
Austria 1 2%
Unknown 50 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 28%
Student > Bachelor 10 19%
Researcher 9 17%
Student > Master 8 15%
Professor > Associate Professor 3 6%
Other 8 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 32%
Engineering 10 19%
Biochemistry, Genetics and Molecular Biology 8 15%
Medicine and Dentistry 6 11%
Chemistry 4 8%
Other 8 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2015.
All research outputs
#4,419,646
of 5,307,787 outputs
Outputs from Lab on a Chip - Miniaturisation for Chemistry & Biology
#1,326
of 1,882 outputs
Outputs of similar age
#140,287
of 172,785 outputs
Outputs of similar age from Lab on a Chip - Miniaturisation for Chemistry & Biology
#61
of 131 outputs
Altmetric has tracked 5,307,787 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,882 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.