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Overview of attention for article published in BMC Developmental Biology, January 2001
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#16 of 329)
  • High Attention Score compared to outputs of the same age (87th percentile)

Mentioned by

patent
9 patents
wikipedia
1 Wikipedia page

Citations

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2190 Dimensions

Readers on

mendeley
1077 Mendeley
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Title
Published in
BMC Developmental Biology, January 2001
DOI 10.1186/1471-213x-1-4
Pubmed ID
Authors

Shankar Srinivas, Tomoko Watanabe, Chyuan-Sheng Lin, Chris M William, Yasuto Tanabe, Thomas M Jessell, Frank Costantini

Abstract

Several Cre reporter strains of mice have been described, in which a lacZ gene is turned on in cells expressing Cre recombinase, as well as their daughter cells, following Cre-mediated excision of a loxP-flanked transcriptional "stop" sequence. These mice are useful for cell lineage tracing experiments as well as for monitoring the expression of Cre transgenes. The green fluorescent protein (GFP) and variants such as EYFP and ECFP offer an advantage over lacZ as a reporter, in that they can be easily visualized without recourse to the vital substrates required to visualize beta-gal in living tissue. In view of the general utility of targeting the ubiquitously expressed ROSA26 locus, we constructed a generic ROSA26 targeting vector. We then generated two reporter lines of mice by inserting EYFP or ECFP cDNAs into the ROSA26 locus, preceded by a loxP-flanked stop sequence. These strains were tested by crossing them with transgenic strains expressing Cre in a ubiquitous (beta-actin-Cre) or a cell-specific (Isl1-Cre and En1-Cre) pattern. The resulting EYFP or ECFP expression patterns indicated that the reporter strains function as faithful monitors of Cre activity. In contrast to existing lacZ reporter lines, where lacZ expression cannot easily be detected in living tissue, the EYFP and ECFP reporter strains are useful for monitoring the expression of Cre and tracing the lineage of these cells and their descendants in cultured embryos or organs. The non-overlapping emission spectra of EYFP and ECFP make them ideal for double labeling studies in living tissues.

Mendeley readers

The data shown below were compiled from readership statistics for 1,077 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 21 2%
Germany 12 1%
United Kingdom 6 <1%
Japan 5 <1%
France 4 <1%
Spain 3 <1%
Sweden 3 <1%
Italy 3 <1%
India 2 <1%
Other 12 1%
Unknown 1006 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 323 30%
Researcher 249 23%
Student > Master 106 10%
Professor > Associate Professor 77 7%
Student > Bachelor 66 6%
Other 186 17%
Unknown 70 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 518 48%
Biochemistry, Genetics and Molecular Biology 176 16%
Medicine and Dentistry 124 12%
Neuroscience 95 9%
Immunology and Microbiology 61 6%
Other 23 2%
Unknown 80 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2020.
All research outputs
#1,557,049
of 15,534,842 outputs
Outputs from BMC Developmental Biology
#16
of 329 outputs
Outputs of similar age
#23,567
of 194,952 outputs
Outputs of similar age from BMC Developmental Biology
#1
of 1 outputs
Altmetric has tracked 15,534,842 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 329 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,952 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them