Rearrangement of the p53 gene in human osteogenic sarcomas.
Proceedings of the National Academy of Sciences of the United States of America, November 1987
H. Masuda, C. Miller, H. P. Koeffler, H. Battifora, M. J. Cline
p53 is a 53-kDa nuclear protein that is associated with malignant transformation in several tumor model systems. In a survey of 134 human carcinomas, sarcomas, leukemias, and lymphomas obtained at surgery or from peripheral blood, we found rearrangements of the p53 gene only in osteogenic sarcomas (3 of 6 osteogenic sarcomas examined). Normal tissue from one of these patients had an unrearranged gene, indicating that the genetic abnormality in the tumor was acquired. Two of the sarcomas with rearranged genes expressed levels of p53 protein that were elevated relative to other tumors. Rearranged p53 genes were also found in human osteogenic sarcoma cell lines.
|Readers by professional status||Count||As %|
|Student > Bachelor||13||26%|
|Student > Ph. D. Student||10||20%|
|Student > Master||6||12%|
|Student > Postgraduate||2||4%|
|Readers by discipline||Count||As %|
|Agricultural and Biological Sciences||18||36%|
|Medicine and Dentistry||12||24%|
|Biochemistry, Genetics and Molecular Biology||11||22%|
|Business, Management and Accounting||1||2%|
|Earth and Planetary Sciences||1||2%|