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Rearrangement of the p53 gene in human osteogenic sarcomas.

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, November 1987
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

patent
4 patents

Citations

dimensions_citation
383 Dimensions

Readers on

mendeley
50 Mendeley
Title
Rearrangement of the p53 gene in human osteogenic sarcomas.
Published in
Proceedings of the National Academy of Sciences of the United States of America, November 1987
DOI 10.1073/pnas.84.21.7716
Pubmed ID
Authors

H. Masuda, C. Miller, H. P. Koeffler, H. Battifora, M. J. Cline

Abstract

p53 is a 53-kDa nuclear protein that is associated with malignant transformation in several tumor model systems. In a survey of 134 human carcinomas, sarcomas, leukemias, and lymphomas obtained at surgery or from peripheral blood, we found rearrangements of the p53 gene only in osteogenic sarcomas (3 of 6 osteogenic sarcomas examined). Normal tissue from one of these patients had an unrearranged gene, indicating that the genetic abnormality in the tumor was acquired. Two of the sarcomas with rearranged genes expressed levels of p53 protein that were elevated relative to other tumors. Rearranged p53 genes were also found in human osteogenic sarcoma cell lines.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
Italy 1 2%
Canada 1 2%
Singapore 1 2%
United States 1 2%
Unknown 45 90%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 26%
Student > Ph. D. Student 10 20%
Researcher 9 18%
Student > Master 6 12%
Student > Postgraduate 2 4%
Other 5 10%
Unknown 5 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 36%
Medicine and Dentistry 12 24%
Biochemistry, Genetics and Molecular Biology 11 22%
Business, Management and Accounting 1 2%
Earth and Planetary Sciences 1 2%
Other 1 2%
Unknown 6 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 1994.
All research outputs
#2,774,916
of 10,292,367 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#31,742
of 62,556 outputs
Outputs of similar age
#32,213
of 98,709 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#326
of 502 outputs
Altmetric has tracked 10,292,367 research outputs across all sources so far. This one has received more attention than most of these and is in the 54th percentile.
So far Altmetric has tracked 62,556 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.8. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 98,709 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 502 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.