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A novel multiple-stage antimalarial agent that inhibits protein synthesis

Overview of attention for article published in Nature, June 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
25 news outlets
blogs
6 blogs
twitter
227 tweeters
peer_reviews
1 peer review site
facebook
18 Facebook pages
reddit
1 Redditor
video
1 video uploader

Citations

dimensions_citation
170 Dimensions

Readers on

mendeley
416 Mendeley
citeulike
4 CiteULike
Title
A novel multiple-stage antimalarial agent that inhibits protein synthesis
Published in
Nature, June 2015
DOI 10.1038/nature14451
Pubmed ID
Authors

Beatriz Baragaña, Irene Hallyburton, Marcus C. S. Lee, Neil R. Norcross, Raffaella Grimaldi, Thomas D. Otto, William R. Proto, Andrew M. Blagborough, Stephan Meister, Grennady Wirjanata, Andrea Ruecker, Leanna M. Upton, Tara S. Abraham, Mariana J. Almeida, Anupam Pradhan, Achim Porzelle, María Santos Martínez, Judith M. Bolscher, Andrew Woodland, Torsten Luksch, Suzanne Norval, Fabio Zuccotto, John Thomas, Frederick Simeons, Laste Stojanovski, Maria Osuna-Cabello, Paddy M. Brock, Tom S. Churcher, Katarzyna A. Sala, Sara E. Zakutansky, María Belén Jiménez-Díaz, Laura Maria Sanz, Jennifer Riley, Rajshekhar Basak, Michael Campbell, Vicky M. Avery, Robert W. Sauerwein, Koen J. Dechering, Rintis Noviyanti, Brice Campo, Julie A. Frearson, Iñigo Angulo-Barturen, Santiago Ferrer-Bazaga, Francisco Javier Gamo, Paul G. Wyatt, Didier Leroy, Peter Siegl, Michael J. Delves, Dennis E. Kyle, Sergio Wittlin, Jutta Marfurt, Ric N. Price, Robert E. Sinden, Elizabeth A. Winzeler, Susan A. Charman, Lidiya Bebrevska, David W. Gray, Simon Campbell, Alan H. Fairlamb, Paul A. Willis, Julian C. Rayner, David A. Fidock, Kevin D. Read, Ian H. Gilbert

Abstract

There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to overcome emerging drug resistance. Here we describe the discovery of DDD107498, a compound with a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite, with good pharmacokinetic properties and an acceptable safety profile. DDD107498 demonstrates potential to address a variety of clinical needs, including single-dose treatment, transmission blocking and chemoprotection. DDD107498 was developed from a screening programme against blood-stage malaria parasites; its molecular target has been identified as translation elongation factor 2 (eEF2), which is responsible for the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis. This discovery of eEF2 as a viable antimalarial drug target opens up new possibilities for drug discovery.

Twitter Demographics

The data shown below were collected from the profiles of 227 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 416 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 5 1%
France 3 <1%
Portugal 2 <1%
Germany 2 <1%
Canada 1 <1%
India 1 <1%
Malaysia 1 <1%
Vietnam 1 <1%
Argentina 1 <1%
Other 4 <1%
Unknown 395 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 104 25%
Researcher 97 23%
Student > Master 56 13%
Student > Bachelor 40 10%
Other 27 6%
Other 62 15%
Unknown 30 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 142 34%
Chemistry 82 20%
Biochemistry, Genetics and Molecular Biology 60 14%
Medicine and Dentistry 30 7%
Pharmacology, Toxicology and Pharmaceutical Science 18 4%
Other 39 9%
Unknown 45 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 389. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2020.
All research outputs
#31,232
of 14,564,394 outputs
Outputs from Nature
#3,430
of 72,652 outputs
Outputs of similar age
#540
of 234,303 outputs
Outputs of similar age from Nature
#126
of 960 outputs
Altmetric has tracked 14,564,394 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 72,652 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 80.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,303 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 960 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.