Title |
Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report
|
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Published in |
Journal of Medical Case Reports, October 2011
|
DOI | 10.1186/1752-1947-5-516 |
Pubmed ID | |
Authors |
Diego M Marzese, Francisco E Gago, Javier I Orozco, Olga M Tello, María Roqué, Laura M Vargas-Roig |
Abstract |
Giant fibroadenoma is an uncommon variant of benign breast lesions. Aberrant methylation of CpG islands in promoter regions is known to be involved in the silencing of genes (for example, tumor-suppressor genes) and appears to be an early event in the etiology of breast carcinogenesis. Only hypermethylation of p16INK4a has been reported in non-giant breast fibroadenoma. In this particular case, there are no previously published data on epigenetic alterations in giant fibroadenomas. Our previous results, based on the analysis of 49 cancer-related CpG islands have confirmed that the aberrant methylation is specific to malignant breast tumors and that it is completely absent in normal breast tissue and breast fibroadenomas. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Researcher | 3 | 25% |
Student > Doctoral Student | 2 | 17% |
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