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Severe falciparum malaria treated with artesunate complicated by delayed onset haemolysis and acute kidney injury

Overview of attention for article published in Malaria Journal, June 2015
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  • Good Attention Score compared to outputs of the same age (68th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

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5 tweeters
facebook
1 Facebook page

Citations

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14 Dimensions

Readers on

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34 Mendeley
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Title
Severe falciparum malaria treated with artesunate complicated by delayed onset haemolysis and acute kidney injury
Published in
Malaria Journal, June 2015
DOI 10.1186/s12936-015-0760-x
Pubmed ID
Authors

Katherine Plewes, Md Shafiul Haider, Hugh W F Kingston, Tsin W Yeo, Aniruddha Ghose, Md Amir Hossain, Arjen M Dondorp, Gareth D H Turner, Nicholas M Anstey

Abstract

Severe falciparum malaria may be complicated by haemolysis after parasite clearance, however the mechanisms remain unclear. Recent reports describe a pattern of delayed onset haemolysis among non-immune travellers with hyperparasitaemia treated with intravenous artesunate, termed post-artesunate delayed haemolysis (PADH). The occurrence and clinical impact of PADH following severe malaria infections in areas of unstable transmission are unknown. A 45-year-old Bangladeshi male was initially admitted to a local hospital with severe falciparum malaria complicated by hyperparasitaemia and treated with intravenous artesunate. Twenty days from his first presentation he was readmitted with delayed onset haemolytic anaemia and acute kidney injury. Multiple blood transfusions and haemodialysis were required. Renal biopsy revealed acute tubular injury and haem pigment nephropathy. His haemoglobin and renal function recovered to baseline after 62 days from his second admission. This case highlights the differential diagnosis of post-malaria delayed onset haemolysis, including the recently described syndrome of post-artemisinin delayed haemolysis. The pathophysiology contributing to acute kidney injury in this patient and the limited treatment options are discussed. This report describes PADH complicated by acute kidney injury in an adult patient living in a malaria hypoendemic region who subsequently required blood transfusions and haemodialysis. This case emphasizes the importance of routine follow up of haemoglobin and renal function in artesunate-treated patients who have recovered from severe malaria.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Brazil 1 3%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Unspecified 8 24%
Researcher 5 15%
Student > Bachelor 4 12%
Student > Master 4 12%
Other 4 12%
Other 9 26%
Readers by discipline Count As %
Medicine and Dentistry 20 59%
Unspecified 7 21%
Biochemistry, Genetics and Molecular Biology 3 9%
Agricultural and Biological Sciences 1 3%
Economics, Econometrics and Finance 1 3%
Other 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2015.
All research outputs
#1,319,231
of 5,320,841 outputs
Outputs from Malaria Journal
#608
of 2,117 outputs
Outputs of similar age
#57,697
of 185,425 outputs
Outputs of similar age from Malaria Journal
#37
of 98 outputs
Altmetric has tracked 5,320,841 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 2,117 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 185,425 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.