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Severe falciparum malaria treated with artesunate complicated by delayed onset haemolysis and acute kidney injury

Overview of attention for article published in Malaria Journal, June 2015
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  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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7 X users
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1 Facebook page

Citations

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26 Dimensions

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66 Mendeley
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Title
Severe falciparum malaria treated with artesunate complicated by delayed onset haemolysis and acute kidney injury
Published in
Malaria Journal, June 2015
DOI 10.1186/s12936-015-0760-x
Pubmed ID
Authors

Katherine Plewes, Md Shafiul Haider, Hugh W F Kingston, Tsin W Yeo, Aniruddha Ghose, Md Amir Hossain, Arjen M Dondorp, Gareth D H Turner, Nicholas M Anstey

Abstract

Severe falciparum malaria may be complicated by haemolysis after parasite clearance, however the mechanisms remain unclear. Recent reports describe a pattern of delayed onset haemolysis among non-immune travellers with hyperparasitaemia treated with intravenous artesunate, termed post-artesunate delayed haemolysis (PADH). The occurrence and clinical impact of PADH following severe malaria infections in areas of unstable transmission are unknown. A 45-year-old Bangladeshi male was initially admitted to a local hospital with severe falciparum malaria complicated by hyperparasitaemia and treated with intravenous artesunate. Twenty days from his first presentation he was readmitted with delayed onset haemolytic anaemia and acute kidney injury. Multiple blood transfusions and haemodialysis were required. Renal biopsy revealed acute tubular injury and haem pigment nephropathy. His haemoglobin and renal function recovered to baseline after 62 days from his second admission. This case highlights the differential diagnosis of post-malaria delayed onset haemolysis, including the recently described syndrome of post-artemisinin delayed haemolysis. The pathophysiology contributing to acute kidney injury in this patient and the limited treatment options are discussed. This report describes PADH complicated by acute kidney injury in an adult patient living in a malaria hypoendemic region who subsequently required blood transfusions and haemodialysis. This case emphasizes the importance of routine follow up of haemoglobin and renal function in artesunate-treated patients who have recovered from severe malaria.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Brazil 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 14%
Researcher 9 14%
Student > Master 8 12%
Student > Bachelor 8 12%
Other 4 6%
Other 10 15%
Unknown 18 27%
Readers by discipline Count As %
Medicine and Dentistry 29 44%
Pharmacology, Toxicology and Pharmaceutical Science 4 6%
Unspecified 3 5%
Immunology and Microbiology 3 5%
Nursing and Health Professions 2 3%
Other 9 14%
Unknown 16 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2020.
All research outputs
#6,737,092
of 22,813,792 outputs
Outputs from Malaria Journal
#1,958
of 5,563 outputs
Outputs of similar age
#78,000
of 264,477 outputs
Outputs of similar age from Malaria Journal
#42
of 99 outputs
Altmetric has tracked 22,813,792 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 5,563 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,477 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.