↓ Skip to main content

Hemoglobin A2 values in sickle cell disease patients quantified by high performance liquid chromatography and the influence of alpha thalassemia

Overview of attention for article published in Revista Brasileira de Hematologia e Hemoterapia, September 2015
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
7 Dimensions

Readers on

mendeley
27 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Hemoglobin A2 values in sickle cell disease patients quantified by high performance liquid chromatography and the influence of alpha thalassemia
Published in
Revista Brasileira de Hematologia e Hemoterapia, September 2015
DOI 10.1016/j.bjhh.2015.05.005
Pubmed ID
Authors

Silvana Fahel da Fonseca, Tatiana Amorim, Antônio Purificação, Marilda Gonçalves, Ney Boa-Sorte

Abstract

In sickle cell disease, the quantification of Hb A2 is important for the differential diagnosis between sickle cell anemia (Hb SS) and Hb S/β(0)-thalassemia. To determine Hb A2 levels as quantified by high performance liquid chromatography in patients with sickle cell anemia (Hb SS) and with the SC hemoglobinopathy, with or without concomitant alpha thalassemia. This is a retrospective study of 242 children aged between two and six years with diagnoses of Hb SS or Hb SC. The hemoglobin was evaluated using high performance liquid chromatography and alpha thalassemia [3.7kb deletion (-α(3.7))] was detected by polymerase chain reaction. Patients were classified as homozygous (-α(3.7)/-α(3.7)), heterozygous (-α(3.7)/α), or homozygous wild-type. Analysis of variance was used to compare the mean Hb A2 values between the alpha thalassemia groups. The mean (±standard deviation) Hb A2 concentrations in the Hb SS group (n=135) was 3.68±0.65%. The mean values for individuals with Hb SS and heterozygous (n=28) or homozygous for alpha thalassemia (n=3) were 3.98±0.64% and 4.73±0.25%, respectively. The mean Hb A2 of all the Hb SC patients (n=107) was 4.01±0.507 with 4.29±0.41% and 4.91±0.22% in individuals heterozygous (n=23) and homozygous for alpha thalassemia (n=7), respectively. All patients homozygous for alpha thalassemia had Hb A2 levels above 3.5%. However, Hb A2 values above 5.2% were seen in patients with Hb SS and Hb SC, independently of alpha thalassemia. Hb A2 levels are elevated in patients with Hb S or Hb C, and are directly influenced by the alpha thalassemia genotypes.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 19%
Researcher 4 15%
Other 4 15%
Student > Ph. D. Student 3 11%
Student > Bachelor 3 11%
Other 3 11%
Unknown 5 19%
Readers by discipline Count As %
Medicine and Dentistry 8 30%
Biochemistry, Genetics and Molecular Biology 6 22%
Agricultural and Biological Sciences 3 11%
Nursing and Health Professions 2 7%
Business, Management and Accounting 1 4%
Other 2 7%
Unknown 5 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2015.
All research outputs
#11,065,919
of 12,447,688 outputs
Outputs from Revista Brasileira de Hematologia e Hemoterapia
#156
of 222 outputs
Outputs of similar age
#192,031
of 233,617 outputs
Outputs of similar age from Revista Brasileira de Hematologia e Hemoterapia
#3
of 4 outputs
Altmetric has tracked 12,447,688 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 222 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,617 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.