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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Stress Doppler echocardiography for early detection of systemic sclerosis-associated pulmonary arterial hypertension
|
|---|---|
| Published in |
Arthritis Research & Therapy, June 2015
|
| DOI | 10.1186/s13075-015-0673-7 |
| Pubmed ID | |
| Authors |
Christian Nagel, Philipp Henn, Nicola Ehlken, Antonello D’Andrea, Norbert Blank, Eduardo Bossone, Anke Böttger, Christoph Fiehn, Christine Fischer, Hanns-Martin Lorenz, Frank Stöckl, Ekkehard Grünig, Benjamin Egenlauf |
| Abstract |
In patients with systemic sclerosis (SSc) associated pulmonary arterial hypertension (SSc-APAH) is the leading cause for death. The objective of this prospective screening study was to analyse sensitivity and specificity of stress-Doppler echocardiography (SDE) in detecting pulmonary hypertension (PH). Pulmonary artery pressures and further parameters of PH were assessed by echocardiography and right heart catheterization (RHC) at rest and during exercise in SSc-patients. Investigators of RHC were blinded to the results of non-invasive measurements. Of 76 SSc patients (64 female, mean age 58 ± 14 years), 22 (29 %) had manifest PH confirmed by RHC, with 4 due to concomitant left heart diseases, 3 with lung diseases and 15 patients with SSc-APAH. Echocardiography at rest missed PH-diagnosis in 5 of 22 PH patients using a cut-off value for systolic pulmonary arterial pressures (PASP) > 40 mmHg at rest. The sensitivity of echocardiography at rest was 72.7 % (95 % Confidence Interval (CI) 0.52-0.88), specificity 88.2 % (95 % CI 0.78-0.95). Stress-Doppler-echocardiography missed PH-diagnosis in 1 of the 22 PH-patients using a cut-off value for PASP > 45 mmHg during low-dose exercise and improved sensitivity to 95.2 % (95 % CI 0.81-1.0) but reduced specificity to 84.9 % (95 % CI 0.74-0.93). Reduction of specificity was partly due to concomitant left heart disease. The results of this prospective, cross-sectional study using RHC as gold standard in all patients showed that SDE markedly improved sensitivity in detecting manifest PH to 95.2 % compared to 72.7 % using echocardiography at rest only. Thus, for PH-screening in SSc-patients echocardiography should be performed at rest and during exercise. Clinicaltrials.gov NCT01387035 . Registered 29 June 2011. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 50% |
| Malaysia | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 16% |
| Researcher | 9 | 15% |
| Student > Ph. D. Student | 7 | 11% |
| Other | 5 | 8% |
| Student > Postgraduate | 5 | 8% |
| Other | 11 | 18% |
| Unknown | 15 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 42% |
| Nursing and Health Professions | 7 | 11% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Agricultural and Biological Sciences | 2 | 3% |
| Immunology and Microbiology | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 19 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2015.
All research outputs
#14,388,865
of 25,374,917 outputs
Outputs from Arthritis Research & Therapy
#2,095
of 3,380 outputs
Outputs of similar age
#124,652
of 278,845 outputs
Outputs of similar age from Arthritis Research & Therapy
#31
of 66 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,845 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.