Title |
Pertussis vaccines and the challenge of inducing durable immunity
|
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Published in |
Current Opinion in Immunology, June 2015
|
DOI | 10.1016/j.coi.2015.05.008 |
Pubmed ID | |
Authors |
Jason M Warfel, Kathryn M Edwards |
Abstract |
Pertussis has re-emerged as an important public health concern. In the 1990s whole-cell pertussis vaccines were replaced with less reactogenic acellular vaccines consisting of purified pertussis components. However, recent data show that protection from acellular pertussis vaccines is not long-lasting. Antibody levels wane rapidly following vaccination, likely a result of the inability of acellular pertussis antigens to stimulate long-lasting B cell memory. In addition, T cell responses to acellular pertussis vaccines are mixed Th2/Th1, while whole-cell pertussis vaccination and infection stimulate Th17 responses, important for host defense against extracellular mucosal pathogens. Consistent with this T cell skewing, acellular vaccines did not prevent colonization or transmission following challenge in nonhuman primates while whole-cell vaccinated and previously infected animals cleared the infection more rapidly. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | 1% |
France | 1 | 1% |
Canada | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 72 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 20% |
Researcher | 12 | 16% |
Student > Doctoral Student | 7 | 9% |
Student > Bachelor | 7 | 9% |
Other | 5 | 7% |
Other | 16 | 21% |
Unknown | 14 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 18% |
Immunology and Microbiology | 13 | 17% |
Medicine and Dentistry | 13 | 17% |
Biochemistry, Genetics and Molecular Biology | 11 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 7 | 9% |
Unknown | 16 | 21% |