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Regional pressure and temperature variations across the injured human brain: comparisons between paired intraparenchymal and ventricular measurements

Overview of attention for article published in Critical Care, December 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)

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3 tweeters
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1 Facebook page

Citations

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8 Dimensions

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44 Mendeley
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Title
Regional pressure and temperature variations across the injured human brain: comparisons between paired intraparenchymal and ventricular measurements
Published in
Critical Care, December 2015
DOI 10.1186/s13054-015-0982-x
Pubmed ID
Authors

Charmaine Childs, Liang Shen

Abstract

Intraparenchymal, multimodality sensors are commonly used in the management of patients with severe traumatic brain injury (TBI). The 'gold standard', based on accuracy, reliability and cost for intracranial pressure (ICP) monitoring is within the cerebral ventricle (external strain gauge). There are no standards yet for intracerebral temperature monitoring and little is known of temperature differences between brain tissue and ventricle. The aim of the study therefore was to determine pressure and temperature differences at intraparenchymal and ventricular sites during five days of continuous neuromonitoring. Patients with severe TBI requiring emergency surgery. patients who required ICP monitoring were eligible for recruitment. Two intracerebral probe types were used: a) intraventricular, dual parameter sensor (measuring pressure, temperature) with inbuilt catheter for CSF drainage: b) multiparameter intraparenchymal sensor measuring pressure, temperature and oxygen partial pressure. All sensors were inserted during surgery and under aseptic conditions. Seventeen patients, 12 undergoing neurosurgery (decompressive craniectomy n = 8, craniotomy n = 4) aged 21-78 years were studied. Agreement of measures for 9540 brain tissue-ventricular temperature 'pairs' and 10,291 brain tissue-ventricular pressure 'pairs' were determined using mixed model to compare mean temperature and pressure for longitudinal data. There was no significant overall difference for mean temperature (p = 0.92) or mean pressure readings (p = 0.379) between tissue and ventricular sites. With 95.8 % of paired temperature readings within 2SD (-0.4 to 0.4 °C) differences in temperature between brain tissue and ventricle were clinically insignificant. For pressure, 93.5 % of readings pairs fell within the 2SD range (-9.4756 to 7.8112 mmHg). However, for individual patients, agreement for mean tissue-ventricular pressure differences was poor on occasions. There is good overall agreement between paired temperature measurements obtained from deep white matter and brain ventricle in patients with and without early neurosurgery. For paired ICP measurements, 93.5 % of readings were within 2SD of mean difference. Whilst the majority of paired readings were comparable (within 10 mmHg) clinically relevant tissue-ventricular dissociations were noted. Further work is required to unravel the events responsible for short intervals of pressure dissociation before tissue pressure readings can be definitively accepted as a reliable surrogate for ventricular pressure.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Other 5 11%
Student > Ph. D. Student 5 11%
Researcher 5 11%
Student > Master 5 11%
Student > Bachelor 4 9%
Other 9 20%
Unknown 11 25%
Readers by discipline Count As %
Medicine and Dentistry 18 41%
Neuroscience 4 9%
Engineering 3 7%
Psychology 3 7%
Social Sciences 1 2%
Other 2 5%
Unknown 13 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2015.
All research outputs
#7,211,304
of 12,787,140 outputs
Outputs from Critical Care
#3,002
of 4,101 outputs
Outputs of similar age
#97,793
of 231,750 outputs
Outputs of similar age from Critical Care
#8
of 9 outputs
Altmetric has tracked 12,787,140 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,101 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,750 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one.