Title |
Sumo and the cellular stress response
|
---|---|
Published in |
Cell Division, June 2015
|
DOI | 10.1186/s13008-015-0010-1 |
Pubmed ID | |
Authors |
Jorrit M. Enserink |
Abstract |
The ubiquitin family member Sumo has important functions in many cellular processes including DNA repair, transcription and cell division. Numerous studies have shown that Sumo is essential for maintaining cell homeostasis when the cell encounters endogenous or environmental stress, such as osmotic stress, hypoxia, heat shock, genotoxic stress, and nutrient stress. Regulation of transcription is a key component of the Sumo stress response, and multiple mechanisms have been described by which Sumo can regulate transcription. Although many individual substrates have been described that are sumoylated during the Sumo stress response, an emerging concept is modification of entire complexes or pathways by Sumo. This review focuses on the function and regulation of Sumo during the stress response. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | <1% |
United Arab Emirates | 1 | <1% |
France | 1 | <1% |
Unknown | 178 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 41 | 23% |
Researcher | 26 | 14% |
Student > Bachelor | 19 | 10% |
Student > Doctoral Student | 18 | 10% |
Student > Master | 17 | 9% |
Other | 32 | 18% |
Unknown | 28 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 66 | 36% |
Agricultural and Biological Sciences | 57 | 31% |
Immunology and Microbiology | 5 | 3% |
Medicine and Dentistry | 5 | 3% |
Chemistry | 5 | 3% |
Other | 13 | 7% |
Unknown | 30 | 17% |