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Corynebacterium diphtheriae putative tellurite-resistance protein (CDCE8392_0813) contributes to the intracellular survival in human epithelial cells and lethality of Caenorhabditis elegans

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, June 2015
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  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

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7 tweeters

Citations

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12 Dimensions

Readers on

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28 Mendeley
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Title
Corynebacterium diphtheriae putative tellurite-resistance protein (CDCE8392_0813) contributes to the intracellular survival in human epithelial cells and lethality of Caenorhabditis elegans
Published in
Memórias do Instituto Oswaldo Cruz, June 2015
DOI 10.1590/0074-02760140479
Pubmed ID
Authors

Louisy Sanches dos Santos, Camila Azevedo Antunes, Cintia Silva dos Santos, José Augusto Adler Pereira, Priscila Soares Sabbadini, Maria das Graças de Luna, Vasco Azevedo, Raphael Hirata Júnior, Andreas Burkovski, Lídia Maria Buarque de Oliveira Asad, Ana Luíza Mattos-Guaraldi

Abstract

Corynebacterium diphtheriae, the aetiologic agent of diphtheria, also represents a global medical challenge because of the existence of invasive strains as causative agents of systemic infections. Although tellurite (TeO32-) is toxic to most microorganisms, TeO32--resistant bacteria, including C. diphtheriae, exist in nature. The presence of TeO32--resistance (TeR) determinants in pathogenic bacteria might provide selective advantages in the natural environment. In the present study, we investigated the role of the putative TeR determinant (CDCE8392_813 gene) in the virulence attributes of diphtheria bacilli. The disruption of CDCE8392_0813 gene expression in the LDCIC-L1 mutant increased susceptibility to TeO32- and reactive oxygen species (hydrogen peroxide), but not to other antimicrobial agents. The LDCIC-L1 mutant also showed a decrease in both the lethality of Caenorhabditis elegans and the survival inside of human epithelial cells compared to wild-type strain. Conversely, the haemagglutinating activity and adherence to and formation of biofilms on different abiotic surfaces were not regulated through the CDCE8392_0813 gene. In conclusion, the CDCE8392_813 gene contributes to the TeR and pathogenic potential of C. diphtheriae.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 21%
Student > Ph. D. Student 4 14%
Other 2 7%
Student > Master 2 7%
Student > Bachelor 2 7%
Other 5 18%
Unknown 7 25%
Readers by discipline Count As %
Medicine and Dentistry 6 21%
Agricultural and Biological Sciences 5 18%
Immunology and Microbiology 4 14%
Biochemistry, Genetics and Molecular Biology 3 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 3 11%
Unknown 6 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2016.
All research outputs
#3,478,806
of 12,511,869 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#119
of 862 outputs
Outputs of similar age
#67,010
of 234,070 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#2
of 3 outputs
Altmetric has tracked 12,511,869 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 862 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,070 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.