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RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies

Overview of attention for article published in Molecular BioSystems, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
13 tweeters
facebook
1 Facebook page

Readers on

mendeley
50 Mendeley
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Title
RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies
Published in
Molecular BioSystems, January 2015
DOI 10.1039/c5mb00278h
Pubmed ID
Authors

Meenakshi Malhotra, André Toulouse, Bruno M. D. C. Godinho, David John Mc Carthy, John F. Cryan, Caitriona M. O'Driscoll

Abstract

Malignant primary brain tumors are aggressive cancerous cells that invade the surrounding tissues of the central nervous system. The current treatment options for malignant brain tumors are limited due to the inability to cross the blood-brain barrier. The advancements in current research has identified and characterized certain molecular markers that are essential for tumor survival, progression, metastasis and angiogenesis. These molecular markers have served as therapeutic targets for the RNAi based therapies, which enable site-specific silencing of the gene responsible for tumor proliferation. However, to bring about therapeutic success, an efficient delivery carrier that can cross the blood-brain barrier and reach the targeted site is essential. The current review focuses on the potential of targeted, non-viral and viral particles containing RNAi therapeutic molecules as delivery strategies specifically for brain tumors.

Twitter Demographics

The data shown below were collected from the profiles of 13 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 49 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 24%
Student > Master 11 22%
Researcher 7 14%
Student > Bachelor 5 10%
Student > Doctoral Student 3 6%
Other 7 14%
Unknown 5 10%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 16%
Agricultural and Biological Sciences 8 16%
Engineering 6 12%
Chemistry 5 10%
Medicine and Dentistry 4 8%
Other 10 20%
Unknown 9 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2015.
All research outputs
#2,387,845
of 13,431,750 outputs
Outputs from Molecular BioSystems
#143
of 1,327 outputs
Outputs of similar age
#47,126
of 234,053 outputs
Outputs of similar age from Molecular BioSystems
#7
of 56 outputs
Altmetric has tracked 13,431,750 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,327 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 234,053 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.