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Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas

Overview of attention for article published in Cancer Discovery, June 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

twitter
10 tweeters
patent
2 patents

Citations

dimensions_citation
107 Dimensions

Readers on

mendeley
134 Mendeley
citeulike
1 CiteULike
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Title
Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas
Published in
Cancer Discovery, June 2015
DOI 10.1158/2159-8290.cd-15-0274
Pubmed ID
Authors

O. A. Zill, C. Greene, D. Sebisanovic, L. M. Siew, J. Leng, M. Vu, A. E. Hendifar, Z. Wang, C. E. Atreya, R. K. Kelley, K. Van Loon, A. H. Ko, M. A. Tempero, T. G. Bivona, P. N. Munster, A. Talasaz, E. A. Collisson

Abstract

Patients with pancreatic and biliary carcinomas lack personalized treatment options, in part because biopsies are often inadequate for molecular characterization. Cell-free DNA (cfDNA) sequencing may enable a precision oncology approach in this setting. We attempted to prospectively analyze 54 genes in tumor and cfDNA for 26 patients. Tumor sequencing failed in nine patients (35%). In the remaining 17, 90.3% (95% CI: 73.1-97.5%) of mutations detected in tumor biopsies were also detected in cfDNA. The diagnostic accuracy of cfDNA sequencing was 97.7%, with 92.3% average sensitivity and 100% specificity across five informative genes. Changes in cfDNA correlated well with tumor marker dynamics in serial sampling (r=0.93). We demonstrate that cfDNA sequencing is feasible, accurate, and sensitive in identifying tumor-derived mutations without prior knowledge of tumor genotype or the abundance of circulating tumor DNA. cfDNA sequencing should be considered in pancreatobiliary cancer trials where tissue sampling is unsafe, infeasible, or otherwise unsuccessful.

Twitter Demographics

The data shown below were collected from the profiles of 10 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Japan 1 <1%
Ireland 1 <1%
United Kingdom 1 <1%
Unknown 128 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 42 31%
Student > Ph. D. Student 22 16%
Other 14 10%
Unspecified 12 9%
Student > Master 10 7%
Other 34 25%
Readers by discipline Count As %
Medicine and Dentistry 45 34%
Agricultural and Biological Sciences 36 27%
Biochemistry, Genetics and Molecular Biology 24 18%
Unspecified 18 13%
Computer Science 3 2%
Other 8 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2018.
All research outputs
#1,600,101
of 13,133,657 outputs
Outputs from Cancer Discovery
#426
of 2,150 outputs
Outputs of similar age
#35,829
of 232,069 outputs
Outputs of similar age from Cancer Discovery
#14
of 71 outputs
Altmetric has tracked 13,133,657 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,150 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.0. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,069 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.