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Indole trimers with antibacterial activity against Gram-positive organisms produced using combinatorial biocatalysis

Overview of attention for article published in AMB Express, June 2015
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Mentioned by

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1 tweeter

Citations

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6 Dimensions

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14 Mendeley
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Title
Indole trimers with antibacterial activity against Gram-positive organisms produced using combinatorial biocatalysis
Published in
AMB Express, June 2015
DOI 10.1186/s13568-015-0125-4
Pubmed ID
Authors

Kevin McClay, Shahila Mehboob, Jerry Yu, Bernard D Santarsiero, Jiangping Deng, James L Cook, Hyunyoung Jeong, Michael E Johnson, Robert J Steffan

Abstract

The I100V isoform of toluene-4-monooxygenase was used to catalyze the oxidative polymerization of anthranil and various indoles under mildly acidic conditions, favoring the production of trimers. Compounds produced in sufficient yield were purified and tested for their ability to inhibit the growth of B. anthracis, E. faecalis, L. monocytogenes, S. aureus, and in some cases, F. tularensis. 15 of the compounds displayed promising antibacterial activity (MIC < 5 µg/ml) against one or more of the strains tested, with the best MIC values being <0.8 µg/ml. All of these compounds had good selectivity, showing minimal cytotoxicity towards HepG2 cells. The structure was solved for six of the compounds that could be crystallized, revealing that minimally two classes of indole based trimers were produced. One compound class produced was a group of substituted derivatives of the natural product 2,2-bis(3-indolyl) indoxyl. The other group of compounds identified was classified as tryptanthrin-like compounds, all having multi-ring pendant groups attached at position 11 of tryptanthrin. One compound of particular interest, SAB-J85, had a structure that suggests that any compound, with a ring structure that can be activated by an oxygenase, might serve as a substrate for combinatorial biocatalysis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 29%
Student > Master 2 14%
Student > Doctoral Student 2 14%
Professor 1 7%
Unknown 5 36%
Readers by discipline Count As %
Chemistry 3 21%
Immunology and Microbiology 3 21%
Biochemistry, Genetics and Molecular Biology 2 14%
Unknown 6 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2015.
All research outputs
#2,800,324
of 5,278,250 outputs
Outputs from AMB Express
#115
of 255 outputs
Outputs of similar age
#103,130
of 186,465 outputs
Outputs of similar age from AMB Express
#11
of 19 outputs
Altmetric has tracked 5,278,250 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 255 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,465 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.