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Apoptotic cell-linked immunoregulation: implications for promoting immune tolerance in transplantation

Overview of attention for article published in Cell & Bioscience, June 2015
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Mentioned by

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2 tweeters

Citations

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4 Dimensions

Readers on

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10 Mendeley
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Title
Apoptotic cell-linked immunoregulation: implications for promoting immune tolerance in transplantation
Published in
Cell & Bioscience, June 2015
DOI 10.1186/s13578-015-0019-9
Pubmed ID
Authors

Ruixia Kuang, Sylvain Perruche, WanJun Chen

Abstract

The induction of alloantigen-specific immune tolerance is the "Holy-Grail" in transplantation. Although it had been previously demonstrated that transient depletion of T cells through apoptosis could lead to long-term immune tolerance, the underlying mechanism responsible for this tolerance induction and maintenance was unknown. In this short article, a novel mechanism for long-term immune tolerance via transient T cell apoptosis will be discussed, based on our recent findings in a CD3-specific antibody treatment-induced immune tolerance mouse model. Transforming growth factor-β, which is produced by immature dendritic cells whilst they phagocytose apoptotic T cells and by macrophages, plays an important role in initiating long-term immune tolerance. A possible model of how allospecific-immune tolerance can be induced in order to prevent allograft rejection in transplantation will be also proposed.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 3 30%
Researcher 3 30%
Student > Postgraduate 1 10%
Other 1 10%
Librarian 1 10%
Other 1 10%
Readers by discipline Count As %
Unspecified 3 30%
Medicine and Dentistry 2 20%
Immunology and Microbiology 2 20%
Nursing and Health Professions 1 10%
Computer Science 1 10%
Other 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2015.
All research outputs
#2,619,141
of 5,279,944 outputs
Outputs from Cell & Bioscience
#58
of 155 outputs
Outputs of similar age
#93,652
of 186,292 outputs
Outputs of similar age from Cell & Bioscience
#4
of 9 outputs
Altmetric has tracked 5,279,944 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 155 research outputs from this source. They receive a mean Attention Score of 2.1. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,292 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.