Title |
Apoptotic cell-linked immunoregulation: implications for promoting immune tolerance in transplantation
|
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Published in |
Cell & Bioscience, June 2015
|
DOI | 10.1186/s13578-015-0019-9 |
Pubmed ID | |
Authors |
Ruixia Kuang, Sylvain Perruche, WanJun Chen |
Abstract |
The induction of alloantigen-specific immune tolerance is the "Holy-Grail" in transplantation. Although it had been previously demonstrated that transient depletion of T cells through apoptosis could lead to long-term immune tolerance, the underlying mechanism responsible for this tolerance induction and maintenance was unknown. In this short article, a novel mechanism for long-term immune tolerance via transient T cell apoptosis will be discussed, based on our recent findings in a CD3-specific antibody treatment-induced immune tolerance mouse model. Transforming growth factor-β, which is produced by immature dendritic cells whilst they phagocytose apoptotic T cells and by macrophages, plays an important role in initiating long-term immune tolerance. A possible model of how allospecific-immune tolerance can be induced in order to prevent allograft rejection in transplantation will be also proposed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 19% |
Student > Master | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Librarian | 1 | 6% |
Other | 1 | 6% |
Other | 1 | 6% |
Unknown | 6 | 38% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 4 | 25% |
Medicine and Dentistry | 2 | 13% |
Agricultural and Biological Sciences | 1 | 6% |
Arts and Humanities | 1 | 6% |
Computer Science | 1 | 6% |
Other | 1 | 6% |
Unknown | 6 | 38% |