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Viroporins, Examples of the Two-Stage Membrane Protein Folding Model

Overview of attention for article published in Viruses (1999-4915), June 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

news
1 news outlet
twitter
4 tweeters

Citations

dimensions_citation
9 Dimensions

Readers on

mendeley
29 Mendeley
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Title
Viroporins, Examples of the Two-Stage Membrane Protein Folding Model
Published in
Viruses (1999-4915), June 2015
DOI 10.3390/v7072781
Pubmed ID
Authors

Luis Martinez-Gil, Ismael Mingarro

Abstract

Viroporins are small, α-helical, hydrophobic virus encoded proteins, engineered to form homo-oligomeric hydrophilic pores in the host membrane. Viroporins participate in multiple steps of the viral life cycle, from entry to budding. As any other membrane protein, viroporins have to find the way to bury their hydrophobic regions into the lipid bilayer. Once within the membrane, the hydrophobic helices of viroporins interact with each other to form higher ordered structures required to correctly perform their porating activities. This two-step process resembles the two-stage model proposed for membrane protein folding by Engelman and Poppot. In this review we use the membrane protein folding model as a leading thread to analyze the mechanism and forces behind the membrane insertion and folding of viroporins. We start by describing the transmembrane segment architecture of viroporins, including the number and sequence characteristics of their membrane-spanning domains. Next, we connect the differences found among viroporin families to their viral genome organization, and finalize focusing on the pathways used by viroporins in their way to the membrane and on the transmembrane helix-helix interactions required to achieve proper folding and assembly.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Sri Lanka 1 3%
Unknown 27 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 21%
Researcher 6 21%
Student > Master 4 14%
Student > Bachelor 3 10%
Professor 3 10%
Other 5 17%
Unknown 2 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 31%
Immunology and Microbiology 4 14%
Agricultural and Biological Sciences 3 10%
Chemistry 3 10%
Engineering 2 7%
Other 4 14%
Unknown 4 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2020.
All research outputs
#2,020,584
of 17,648,139 outputs
Outputs from Viruses (1999-4915)
#509
of 4,840 outputs
Outputs of similar age
#31,583
of 238,920 outputs
Outputs of similar age from Viruses (1999-4915)
#10
of 85 outputs
Altmetric has tracked 17,648,139 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,840 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,920 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.