Title |
Hydrogenated fat intake during pregnancy and lactation caused increase in TRAF-6 and reduced AdipoR1 in white adipose tissue, but not in muscle of 21 days old offspring rats
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Published in |
Lipids in Health and Disease, January 2011
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DOI | 10.1186/1476-511x-10-22 |
Pubmed ID | |
Authors |
Juliana L de Oliveira, Lila M Oyama, Ana Cláudia L Hachul, Carolina Biz, Eliane B Ribeiro, Claudia M Oller do Nascimento, Luciana P Pisani |
Abstract |
Although lipids transfer through placenta is very limited, modification in dietary fatty acids can lead to implications in fetal and postnatal development. Trans fatty acid (TFA) intake during gestation and lactation have been reported to promote dyslipidemia and increase in pro- inflammatory adipokines in offspring. The aim of this study was to evaluate whether the alterations on pro-inflammatory cytokines and dyslipidemia observed previously in 21-d-old offspring of rats fed a diet containing hydrogenated vegetable fat during gestation and lactation were related to alterations in TLR-4, TRAF-6 and adipo-R1 receptor in white adipose tissue and muscle. On the first day of gestation, rats were randomly divided into two groups: (C) received a control diet, and (T) received a diet enriched with hydrogenated vegetable fat, rich in trans fatty acids. The diets were maintained throughout gestation and lactation. Each mother was given eight male pups. On the 21st day of life the offspring were killed. Blood, soleus and extensor digital longus (EDL) muscles, and retroperitoneal (RET) white adipose tissue were collected. |
X Demographics
Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 17% |
Student > Bachelor | 4 | 13% |
Student > Doctoral Student | 4 | 13% |
Student > Master | 4 | 13% |
Professor | 2 | 7% |
Other | 3 | 10% |
Unknown | 8 | 27% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Medicine and Dentistry | 3 | 10% |
Nursing and Health Professions | 2 | 7% |
Sports and Recreations | 2 | 7% |
Other | 5 | 17% |
Unknown | 10 | 33% |