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An accurate test for homogeneity of odds ratios based on Cochran’s Q-statistic

Overview of attention for article published in BMC Medical Research Methodology, June 2015
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Title
An accurate test for homogeneity of odds ratios based on Cochran’s Q-statistic
Published in
BMC Medical Research Methodology, June 2015
DOI 10.1186/s12874-015-0034-x
Pubmed ID
Authors

Elena Kulinskaya, Michael B Dollinger

Abstract

A frequently used statistic for testing homogeneity in a meta-analysis of K independent studies is Cochran's Q. For a standard test of homogeneity the Q statistic is referred to a chi-square distribution with K-1 degrees of freedom. For the situation in which the effects of the studies are logarithms of odds ratios, the chi-square distribution is much too conservative for moderate size studies, although it may be asymptotically correct as the individual studies become large. Using a mixture of theoretical results and simulations, we provide formulas to estimate the shape and scale parameters of a gamma distribution to fit the distribution of Q. Simulation studies show that the gamma distribution is a good approximation to the distribution for Q. Use of the gamma distribution instead of the chi-square distribution for Q should eliminate inaccurate inferences in assessing homogeneity in a meta-analysis. (A computer program for implementing this test is provided.) This hypothesis test is competitive with the Breslow-Day test both in accuracy of level and in power.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Brazil 1 2%
Unknown 48 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 22%
Researcher 7 14%
Student > Master 7 14%
Other 4 8%
Unspecified 3 6%
Other 7 14%
Unknown 11 22%
Readers by discipline Count As %
Medicine and Dentistry 7 14%
Nursing and Health Professions 5 10%
Mathematics 4 8%
Environmental Science 3 6%
Social Sciences 3 6%
Other 12 24%
Unknown 16 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2015.
All research outputs
#18,417,643
of 22,815,414 outputs
Outputs from BMC Medical Research Methodology
#1,738
of 2,012 outputs
Outputs of similar age
#192,361
of 266,628 outputs
Outputs of similar age from BMC Medical Research Methodology
#6
of 7 outputs
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