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Glucose deprivation in tuberous sclerosis complex-related tumors

Overview of attention for article published in Cell & Bioscience, October 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
9 Dimensions

Readers on

mendeley
32 Mendeley
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Title
Glucose deprivation in tuberous sclerosis complex-related tumors
Published in
Cell & Bioscience, October 2011
DOI 10.1186/2045-3701-1-34
Pubmed ID
Authors

Xiuyun Jiang, Xiuyun Jiang, Heidi L Kenerson, Raymond S Yeung

Abstract

Cancer cells possess unique metabolic phenotypes that are determined by their underlying oncogenic pathways. Activation of the PI3K/Akt/mTOR signaling cascade promotes glycolysis and leads to glucose-dependence in tumors. In particular, cells with constitutive mTORC1 activity secondary to the loss of TSC1/TSC2 function are prone to undergo apoptosis upon glucose withdrawal in vitro, but this concept has not been tested in vivo. This study examines the effects of restricting glucose metabolism by pharmacologic and dietary means in a tuberous sclerosis complex (TSC) tumor xenograft model.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
United States 1 3%
Unknown 30 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 28%
Student > Ph. D. Student 5 16%
Student > Master 5 16%
Other 3 9%
Student > Postgraduate 3 9%
Other 7 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 44%
Medicine and Dentistry 7 22%
Biochemistry, Genetics and Molecular Biology 4 13%
Unspecified 1 3%
Sports and Recreations 1 3%
Other 2 6%
Unknown 3 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2011.
All research outputs
#503,664
of 3,685,988 outputs
Outputs from Cell & Bioscience
#7
of 60 outputs
Outputs of similar age
#8,111
of 66,792 outputs
Outputs of similar age from Cell & Bioscience
#1
of 5 outputs
Altmetric has tracked 3,685,988 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 60 research outputs from this source. They receive a mean Attention Score of 2.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,792 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them