↓ Skip to main content

Increased regulatory T cells in acute lymphoblastic leukemia patients

Overview of attention for article published in Hematology, June 2015
Altmetric Badge


20 Dimensions

Readers on

37 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Increased regulatory T cells in acute lymphoblastic leukemia patients
Published in
Hematology, June 2015
DOI 10.1179/1607845415y.0000000025
Pubmed ID

Siti-Zuleha Idris, Norfarazieda Hassan, Le-Jie Lee, Sabariah Md Noor, Raudhawati Osman, Marsitah Abdul-Jalil, Abdul-Jalil Nordin, Maha Abdullah


Introduction Regulation in adaptive immune response balances a fine line that prevents instigation of self-damage or fall into unresponsiveness permitting abnormal cell growth. Mechanisms that keep this balance in check include regulatory T cells (Tregs). Tregs consist of a small but heterogeneous population which may be identified by the phenotype, CD3+CD4+CD25+CD127-. Role of Tregs in pathogenesis of cancers is thus far supported by evidence of increased Tregs in various cancers and may contribute to poorer prognosis. Tregs may also be important in acute leukemias. Objective A review of the literature on Tregs in acute leukemias was conducted and Tregs were determined in B-cell acute lymphoblastic leukemias (ALLs). Results Studies on Tregs in B-cell ALL are few and controversial. We observed a significantly increased percentage of Tregs (mean ± SD, 9.72 ± 3.79% vs. 7.05 ± 1.74%; P = 0.047) in the bone marrow/peripheral blood of ALL (n = 17) compared to peripheral blood of normal controls (n = 35). A positive trend between Tregs and age (R = 0.474, P = 0.055, n = 17) implicates this factor of poor prognosis in B-cell ALL. Discussion Tregs in cancer are particularly significant in immunotherapy. The manipulation of the immune system to treat cancer has for a long time ignored regulatory mechanisms inducible or in place. In lymphoma studies tumor-specific mechanisms that are unlike conventional methods in the induction of Tregs have been hypothesized. In addition, tumor-infiltrating Tregs may present different profiles from peripheral blood pictures. Tregs will continue to be dissected to reveal their mysteries and their impact on clinical significance.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 16%
Student > Bachelor 4 11%
Lecturer 3 8%
Student > Postgraduate 3 8%
Researcher 3 8%
Other 4 11%
Unknown 14 38%
Readers by discipline Count As %
Medicine and Dentistry 9 24%
Immunology and Microbiology 7 19%
Biochemistry, Genetics and Molecular Biology 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Agricultural and Biological Sciences 1 3%
Other 1 3%
Unknown 13 35%