↓ Skip to main content

Cancer stem cells: a new approach to tumor development

Overview of attention for article published in Revista da Associação Médica Brasileira, February 2015
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
72 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Cancer stem cells: a new approach to tumor development
Published in
Revista da Associação Médica Brasileira, February 2015
DOI 10.1590/1806-9282.61.01.086
Pubmed ID
Authors

Natália Cristina Ciufa Kobayashi, Samuel Marcos Ribeiro de Noronha

Abstract

Many theories have been proposed to explain the origins of cancer. Currently, evidences show that not every tumor cell is capable of initiating a tumor. Only a small part of the cancer cells, called cancer stem cells (CSCs), can generate a tumor identical to the original one, when removed from human tumors and transplanted into immunosuppressed mice. The name given to these cells comes from the resemblance to normal stem cells, except for the fact that their ability to divide is infinite. These cells are also affected by their microenvironment. Many of the signaling pathways, such as Wnt, Notch and Hedgehog, are altered in this tumoral subpopulation, which also contributes to abnormal proliferation. Researchers have found several markers for CSCs; however, much remains to be studied, or perhaps a universal marker does not even exist, since they vary among tumor types and even from patient to patient. It was also found that cancer stem cells are resistant to radiotherapy and chemotherapy. This may explain the re-emergence of the disease, since they are not completely eliminated and minimal amounts of CSCs can repopulate a tumor. Once the diagnosis in the early stages greatly increases the chances of curing cancer, identifying CSCs in tumors is a goal for the development of more effective treatments. The objective of this article is to discuss the origin of cancer according to the theory of stem cell cancer, as well as its markers and therapies used for treatment.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 2 3%
Portugal 1 1%
Unknown 69 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 24%
Student > Ph. D. Student 14 19%
Student > Bachelor 11 15%
Student > Doctoral Student 5 7%
Researcher 5 7%
Other 4 6%
Unknown 16 22%
Readers by discipline Count As %
Medicine and Dentistry 16 22%
Biochemistry, Genetics and Molecular Biology 15 21%
Agricultural and Biological Sciences 14 19%
Immunology and Microbiology 3 4%
Chemistry 3 4%
Other 4 6%
Unknown 17 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2015.
All research outputs
#7,899,142
of 12,589,221 outputs
Outputs from Revista da Associação Médica Brasileira
#151
of 453 outputs
Outputs of similar age
#122,925
of 232,429 outputs
Outputs of similar age from Revista da Associação Médica Brasileira
#8
of 15 outputs
Altmetric has tracked 12,589,221 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 453 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,429 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.