Title |
MIR137HG risk variant rs1625579 genotype is related to corpus callosum volume in schizophrenia
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Published in |
Neuroscience Letters, June 2015
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DOI | 10.1016/j.neulet.2015.06.039 |
Pubmed ID | |
Authors |
Veena S. Patel, Sinead Kelly, Carrie Wright, Cota Navin Gupta, Alejandro Arias-Vasquez, Nora Perrone-Bizzozero, Stefan Ehrlich, Lei Wang, Juan R. Bustillo, Derek Morris, Aiden Corvin, Dara M. Cannon, Colm McDonald, Gary Donohoe, Vince D. Calhoun, Jessica A. Turner |
Abstract |
Genome-wide association studies implicate the MIR137HG risk variant rs1625579 (MIR137HGrv) within the host gene for microRNA-137 as a potential regulator of schizophrenia susceptibility. We examined the influence of MIR137HGrv genotype on 17 subcortical and callosal volumes in a large sample of individuals with schizophrenia and healthy controls (n=841). Although the volumes were overall reduced relative to healthy controls, for individuals with schizophrenia the homozygous MIR137HGrv risk genotype was associated with attenuated reduction of mid-posterior corpus callosum volume (p=0.001), along with trend-level effects in the adjacent central and posterior corpus callosum. These findings are unique in the literature and remain robust after analysis in ethnically homogenous and single-scanner subsets of the larger sample. Thus, our study suggests that the mechanisms whereby MIR137HGrv works to increase schizophrenia risk are not those that generate the corpus callosum volume reductions commonly found in the disorder. |
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Unknown | 2 | 100% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 18% |
Student > Ph. D. Student | 5 | 13% |
Student > Master | 4 | 10% |
Student > Bachelor | 3 | 8% |
Other | 2 | 5% |
Other | 7 | 18% |
Unknown | 12 | 30% |
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Biochemistry, Genetics and Molecular Biology | 7 | 18% |
Agricultural and Biological Sciences | 5 | 13% |
Neuroscience | 5 | 13% |
Medicine and Dentistry | 3 | 8% |
Nursing and Health Professions | 2 | 5% |
Other | 6 | 15% |
Unknown | 12 | 30% |