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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Methotrexate as a steroid sparing agent for asthma in adults
|
|---|---|
| Published in |
Cochrane database of systematic reviews, July 1998
|
| DOI | 10.1002/14651858.cd000391 |
| Pubmed ID | |
| Authors |
Huw Richard H R Davies, Leslie LG Olson, Peter G Gibson |
| Abstract |
Sustained oral corticosteroid use can lead to complications, so there is interest in identifying agents that can reduce oral steroid use in people with asthma. Methotrexate has attracted attention as a possible steroid sparing agent in patients with chronic oral steroid dependent asthma. The objective of this review was to assess the effects of adding methotrexate to oral corticosteroids in adults with stable asthma who are dependent on oral corticosteroids. The Cochrane Airways Group trials register and reference lists of identified articles were searched. Randomised trials of the addition of methotrexate compared with placebo in adult steroid dependent asthmatics. Duration of therapy needed to be at least 12 weeks. Trial quality was assessed and data extraction was carried out by two reviewers independently. Study authors were contacted for missing information. Ten trials involving a total of 185 people were included. Study design and quality, corticosteroid dosages and outcomes varied widely. There was a reduction in oral corticosteroid dose favouring methotrexate in parallel trials (weighted mean difference -4.1 mg per day, 95% confidence interval -6.8 to -1.3) and also in cross-over trials (weighted mean difference -2.9 mg per day, 95% confidence interval -5.9 to -0.2). There was no difference between methotrexate and placebo for forced expiratory volume in one minute (weighted mean difference 0.12 litre, 95% confidence interval -0.21 to 0.45). Hepatotoxicity was a common adverse effect with methotrexate compared to placebo (odds ratio 6.9, 95% confidence interval 3.1 to 15.5). Methotrexate may have a small steroid sparing effect in adults with asthma who are dependent on oral corticosteroids. However, the overall reduction in daily steroid use is probably not large enough to reduce steroid-induced adverse effects. This small potential to reduce the impact of steroid side-effects is probably insufficient to offset the adverse effects of methotrexate. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 2% |
| Unknown | 120 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 18 | 15% |
| Student > Master | 16 | 13% |
| Librarian | 6 | 5% |
| Student > Ph. D. Student | 6 | 5% |
| Other | 6 | 5% |
| Other | 16 | 13% |
| Unknown | 54 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 34% |
| Nursing and Health Professions | 12 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 2% |
| Social Sciences | 2 | 2% |
| Psychology | 2 | 2% |
| Other | 6 | 5% |
| Unknown | 56 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2023.
All research outputs
#5,264,158
of 25,457,858 outputs
Outputs from Cochrane database of systematic reviews
#7,177
of 11,842 outputs
Outputs of similar age
#4,432
of 31,178 outputs
Outputs of similar age from Cochrane database of systematic reviews
#3
of 6 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,842 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.9. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 31,178 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.