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Association of serum bilirubin level with lung function decline: a Korean community-based cohort study

Overview of attention for article published in Respiratory Research, May 2018
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Title
Association of serum bilirubin level with lung function decline: a Korean community-based cohort study
Published in
Respiratory Research, May 2018
DOI 10.1186/s12931-018-0814-z
Pubmed ID
Authors

Ah Young Leem, Ha Yan Kim, Young Sam Kim, Moo Suk Park, Joon Chang, Ji Ye Jung

Abstract

Bilirubin has been reported to be associated with respiratory diseases due to its antioxidant action. We aimed to evaluate the relationship between serum bilirubin concentration and annual lung function decline in the Korean general population. The study included 7986 subjects aged 40-69 years from the Ansung-Ansan cohort database I (2001-2002)-III (2005-2006). We analyzed the relationships between serum bilirubin level and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and mean forced expiratory flow between 25 and 75% of FVC (FEF25-75%) at baseline, as well as the annual average changes in these lung parameters. The FEV1, FVC, and FEF25-75% were significantly associated with serum bilirubin levels after adjustment for age, sex, body mass index (BMI), and smoking status (all P < 0.001). When stratified according to smoking status, these relationships were significant in never-smokers. Additionally, serum bilirubin level was negatively associated with the annual decline in FEV1 and FVC, and positively associated with the annual decline in FEV1/FVC after adjustment for age, sex, BMI, baseline lung function, and smoking status (all P < 0.001). We found significant associations of serum bilirubin levels with FEV1, FVC, and FEF25-75% in the general population, especially in never-smokers. Moreover, serum bilirubin levels were related with the annual decline in FEV1, FVC, and FEV1/FVC ratio.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 19%
Other 2 10%
Lecturer 1 5%
Student > Bachelor 1 5%
Student > Doctoral Student 1 5%
Other 2 10%
Unknown 10 48%
Readers by discipline Count As %
Medicine and Dentistry 6 29%
Nursing and Health Professions 3 14%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Environmental Science 1 5%
Mathematics 1 5%
Other 0 0%
Unknown 9 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2018.
All research outputs
#20,663,600
of 25,382,440 outputs
Outputs from Respiratory Research
#2,702
of 3,062 outputs
Outputs of similar age
#267,991
of 343,952 outputs
Outputs of similar age from Respiratory Research
#71
of 75 outputs
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