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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Elimination of microglia improves cognitive function following cranial irradiation
|
|---|---|
| Published in |
Scientific Reports, August 2016
|
| DOI | 10.1038/srep31545 |
| Pubmed ID | |
| Authors |
Munjal M. Acharya, Kim N. Green, Barrett D. Allen, Allison R. Najafi, Amber Syage, Harutyun Minasyan, Mi T. Le, Takumi Kawashita, Erich Giedzinski, Vipan K. Parihar, Brian L. West, Janet E. Baulch, Charles L. Limoli |
| Abstract |
Cranial irradiation for the treatment of brain cancer elicits progressive and severe cognitive dysfunction that is associated with significant neuropathology. Radiation injury in the CNS has been linked to persistent microglial activation, and we find upregulation of pro-inflammatory genes even 6 weeks after irradiation. We hypothesize that depletion of microglia in the irradiated brain would have a neuroprotective effect. Adult mice received acute head only irradiation (9 Gy) and were administered a dietary inhibitor (PLX5622) of colony stimulating factor-1 receptor (CSF1R) to deplete microglia post-irradiation. Cohorts of mice maintained on a normal and PLX5662 diet were analyzed for cognitive changes using a battery of behavioral tasks 4-6 weeks later. PLX5622 treatment caused a rapid and near complete elimination of microglia in the brain within 3 days of treatment. Irradiation of animals given a normal diet caused characteristic behavioral deficits designed to test medial pre-frontal cortex (mPFC) and hippocampal learning and memory and caused increased microglial activation. Animals receiving the PLX5622 diet exhibited no radiation-induced cognitive deficits, and exhibited near complete loss of IBA-1 and CD68 positive microglia in the mPFC and hippocampus. Our data demonstrate that elimination of microglia through CSF1R inhibition can ameliorate radiation-induced cognitive deficits in mice. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 250 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 250 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 22% |
| Researcher | 27 | 11% |
| Student > Master | 22 | 9% |
| Student > Doctoral Student | 19 | 8% |
| Student > Bachelor | 16 | 6% |
| Other | 45 | 18% |
| Unknown | 66 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 74 | 30% |
| Medicine and Dentistry | 24 | 10% |
| Agricultural and Biological Sciences | 23 | 9% |
| Biochemistry, Genetics and Molecular Biology | 20 | 8% |
| Immunology and Microbiology | 12 | 5% |
| Other | 20 | 8% |
| Unknown | 77 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2022.
All research outputs
#2,080,840
of 22,653,392 outputs
Outputs from Scientific Reports
#18,546
of 121,964 outputs
Outputs of similar age
#40,474
of 355,370 outputs
Outputs of similar age from Scientific Reports
#561
of 3,658 outputs
Altmetric has tracked 22,653,392 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 121,964 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 355,370 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 3,658 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.