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Evidence of heterozygosity and recombinant alleles in single cysts of Giardia duodenalis

Overview of attention for article published in Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária, June 2016
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Title
Evidence of heterozygosity and recombinant alleles in single cysts of Giardia duodenalis
Published in
Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária, June 2016
DOI 10.1590/s1984-29612016031
Pubmed ID
Authors

Juliana Martins Aguiar, Sheila Oliveira Silva, Valdir Azevedo dos Santos, Sueli Akemi Taniwaki, Tricia Maria Ferreira de Sousa Oliveira, Helena Lage Ferreira, Lara Borges Keid, Fábio Gregori, Rodrigo Martins Soares

Abstract

Giardia duodenalis is divided into eight assemblages (named A to H). Isolates of assemblage A are divided into four sub-assemblages (AI, AII, AIII and AIV). While isolates of sub-assemblage AII are almost exclusively detected in human hosts, isolates of assemblage B are encountered in a multitude of animal hosts and humans. Here, we isolated single cysts of G. duodenalis from a human stool sample and found that one of them had overlaps of assemblage AII and B alleles and an unexpectedly high number of variants of the beta-giardin (Bg) and GLORF-C4 (OrfC4) alleles. In addition, one of the Bg alleles of that cyst had a fragment of sub-assemblage AII interspersed with fragments of assemblage B, thus indicating that this allele may be a recombinant between sequences A and B. Our results are unprecedented and put a check on the statement that different assemblages of G. duodenalis represent species with different host specificities.

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The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 11%
Unknown 8 89%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 11%
Unknown 8 89%