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Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion

Overview of attention for article published in American Journal of Physiology: Renal, Fluid & Electrolyte Physiology, May 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

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11 X users

Citations

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Title
Collecting duct principal, but not intercalated, cell prorenin receptor regulates renal sodium and water excretion
Published in
American Journal of Physiology: Renal, Fluid & Electrolyte Physiology, May 2018
DOI 10.1152/ajprenal.00122.2018
Pubmed ID
Authors

Nirupama Ramkumar, Deborah Stuart, Elena Mironova, Nikita Abraham, Yang Gao, Shuping Wang, Jayalakshmi Lakshmipathi, James D Stockand, Donald E Kohan

Abstract

The collecting duct is the predominant nephron site of prorenin and prorenin receptor (PRR) expression. We previously demonstrated that the collecting duct PRR regulates epithelial Na+ channel (ENaC) activity and water transport; however, which cell type is involved remains unclear. Herein, we examined the effects of principal cell (PC) or intercalated cell (IC) PRR deletion on renal Na+ and water handling. PC or IC PRR KO mice were obtained by crossing floxed PRR mice with mice harboring Cre recombinase under the control of the AQP2 or B-1 subunit of the H+ ATPase promoters, respectively. PC KO mice had reduced renal medullary ENaC-α abundance and increased urinary Na+ losses on a low Na+ diet compared to controls. Conversely, IC KO mice had no apparent differences in Na+ balance or ENaC abundance compared to controls. Acute treatment with prorenin increased ENaC channel number and open probability in acutely isolated cortical collecting ducts from control and IC PRR KO, but not PC PRR KO, mice. Further, compared to controls, PC KO, but not IC KO mice, had increased urine volume, reduced urine osmolality, and reduced abundance of renal medullary AQP2. Taken together, these findings indicate that PC, but not IC, PRR modulates ENaC activity, urinary Na+ excretion and water transport.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 17%
Professor > Associate Professor 1 17%
Student > Bachelor 1 17%
Unknown 3 50%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 33%
Agricultural and Biological Sciences 1 17%
Medicine and Dentistry 1 17%
Unknown 2 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2019.
All research outputs
#4,804,830
of 25,382,440 outputs
Outputs from American Journal of Physiology: Renal, Fluid & Electrolyte Physiology
#352
of 2,792 outputs
Outputs of similar age
#86,663
of 343,952 outputs
Outputs of similar age from American Journal of Physiology: Renal, Fluid & Electrolyte Physiology
#8
of 47 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,792 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,952 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.