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The Anti-inflammatory Cytokine, Interleukin (IL)-10, Blocks the Inhibitory Effect of IL-1β on Long Term Potentiation

Overview of attention for article published in Journal of Biological Chemistry, December 2001
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Title
The Anti-inflammatory Cytokine, Interleukin (IL)-10, Blocks the Inhibitory Effect of IL-1β on Long Term Potentiation
Published in
Journal of Biological Chemistry, December 2001
DOI 10.1074/jbc.m108757200
Pubmed ID
Authors

Áine Kelly, Aileen Lynch, Emily Vereker, Yvonne Nolan, Patrice Queenan, Elizabeth Whittaker, Luke A.J. O'Neill, Marina A. Lynch

Abstract

Several effects of the proinflammatory cytokine, interleukin-1 beta (IL-1 beta), have been described in the central nervous system, and one area of the brain where marked changes have been reported is the hippocampus. Among these changes are an IL-1 beta-induced inhibition of long term potentiation (LTP) in perforant path-granule cell synapses and an attenuation of glutamate release in synaptosomes prepared from the hippocampus. Evidence suggests that, at least in circulating cells, the anti-inflammatory cytokine, IL-10, antagonizes certain effects of IL-1. We investigated the effect of IL-10 on IL-1 beta-induced inhibition of LTP and glutamate release. The evidence presented indicates that IL-1 beta stimulates the stress-activated protein kinase, c-Jun-activated protein kinase (JNK), and IL-1 receptor-associated kinase, which may explain its inhibitory effect on release and LTP, and that IL-10 reversed the IL-1 beta-induced stimulation of JNK activity and inhibition of release and LTP. We observed that IL-10 abrogated the stimulatory effect of IL-1 beta on superoxide dismutase activity and reactive oxygen species production, whereas the H(2)O(2)-induced inhibition of LTP was also blocked by IL-10. We present evidence that suggests that the action of IL-10 may be mediated by its ability to induce shedding of the IL-1 type I receptor.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
India 1 2%
Russia 1 2%
Australia 1 2%
Unknown 61 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 26%
Student > Postgraduate 7 11%
Professor > Associate Professor 7 11%
Professor 7 11%
Student > Doctoral Student 5 8%
Other 18 27%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 24%
Medicine and Dentistry 15 23%
Neuroscience 11 17%
Biochemistry, Genetics and Molecular Biology 6 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 5 8%
Unknown 11 17%