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Cross-sectional examination of metabolites and metabolic phenotypes in uremia

Overview of attention for article published in BMC Nephrology, July 2015
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  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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Title
Cross-sectional examination of metabolites and metabolic phenotypes in uremia
Published in
BMC Nephrology, July 2015
DOI 10.1186/s12882-015-0100-y
Pubmed ID
Authors

Sahir Kalim, Clary B. Clish, Joseph J. Deferio, Guillermo Ortiz, Alexander S. Moffet, Robert E. Gerszten, Ravi Thadhani, Eugene P. Rhee

Abstract

Although metabolomic approaches have begun to document numerous changes that arise in end stage renal disease (ESRD), how these alterations relate to established metabolic phenotypes in uremia is unknown. In 200 incident hemodialysis patients we used partial least squares discriminant analysis to identify which among 166 metabolites could best discriminate individuals with or without diabetes, and across tertiles of body mass index, serum albumin, total cholesterol, and systolic blood pressure. Our data do not recapitulate metabolomic signatures of diabetes and obesity identified among individuals with normal renal function (e.g. elevations in branched chain and aromatic amino acids) and highlight several potential markers of diabetes status specific to ESRD, including xanthosine-5-phosphate and vanillylmandelic acid. Further, our data identify significant associations between elevated tryptophan and long-chain acylcarnitine levels and both decreased total cholesterol and systolic blood pressure in ESRD. Higher tryptophan levels were also associated with higher serum albumin levels, but this may reflect tryptophan's significant albumin binding. Finally, an examination of the uremic retention solutes captured by our platform in relation to 24 clinical phenotypes provides a framework for investigating mechanisms of uremic toxicity. In sum, these studies leveraging metabolomic and metabolic phenotype data acquired in a well-characterized ESRD cohort demonstrate striking differences from metabolomics studies in the general population, and may provide clues to novel functional pathways in the ESRD population.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 16%
Researcher 6 16%
Student > Doctoral Student 4 11%
Other 3 8%
Lecturer 2 5%
Other 9 24%
Unknown 7 19%
Readers by discipline Count As %
Medicine and Dentistry 14 38%
Biochemistry, Genetics and Molecular Biology 3 8%
Nursing and Health Professions 3 8%
Agricultural and Biological Sciences 2 5%
Veterinary Science and Veterinary Medicine 1 3%
Other 4 11%
Unknown 10 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2018.
All research outputs
#12,930,368
of 22,816,807 outputs
Outputs from BMC Nephrology
#946
of 2,467 outputs
Outputs of similar age
#115,717
of 262,285 outputs
Outputs of similar age from BMC Nephrology
#19
of 46 outputs
Altmetric has tracked 22,816,807 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,467 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,285 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.