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Case report of a patient with progressive multifocal leukoencephalopathy under treatment with dimethyl fumarate

Overview of attention for article published in BMC Neurology, July 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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2 tweeters

Citations

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31 Dimensions

Readers on

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40 Mendeley
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Title
Case report of a patient with progressive multifocal leukoencephalopathy under treatment with dimethyl fumarate
Published in
BMC Neurology, July 2015
DOI 10.1186/s12883-015-0363-8
Pubmed ID
Authors

Nele Dammeier, Victoria Schubert, Till-Karsten Hauser, Antje Bornemann, Felix Bischof

Abstract

Progressive multifocal leukoencephalopathy is a severe demyelinating disease caused by the polyoma JC virus in patients with reduced immunocompetence. A few cases of progressive multifocal leukoencephalopathy have been reported in patients treated with fumaric acid esters. A 53-year-old Caucasian woman reported to our clinic with a first focal epileptic seizure and mild cognitive impairment. Since 1.5 years, she was treated with fumaderm for her psoriasis. During that time, her lymphocyte counts ranged between 450 and 700/μl. Cerebral magnet resonance imaging showed multifocal subcortical T2 hyperintense lesions with partial gadolinium enhancement. She did not have antibodies against human immunodeficiency virus 1 and 2 and cerebrospinal fluid-polymerase chain reaction for viral infections including a sensitive JC-virus polymerase chain reaction were negative. The diagnosis of progressive multifocal leukoencephalopathy was established by histological analysis and detection of JC-virus desoxyribonucleic acid in brain biopsy specimens. Dimethyl fumarate was stopped and Mirtazapin and Mefloquin were initiated. Neurological examination and imaging remained stable. Progressive multifocal leukoencephalopathy can occur in patients with lymphocyte counts between 450 and 700/μl, produce only faint symptoms and is not excluded by negative JC-virus-polymerase chain reaction in cerebrospinal fluid. The incidence of progressive multifocal leukoencephalopathy may thus be underestimated and a more careful surveillance of patients would be necessary.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 20%
Student > Ph. D. Student 6 15%
Researcher 5 13%
Student > Postgraduate 3 8%
Student > Master 3 8%
Other 7 18%
Unknown 8 20%
Readers by discipline Count As %
Medicine and Dentistry 20 50%
Psychology 4 10%
Neuroscience 3 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Social Sciences 1 3%
Other 2 5%
Unknown 8 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2016.
All research outputs
#6,540,131
of 11,428,083 outputs
Outputs from BMC Neurology
#639
of 1,348 outputs
Outputs of similar age
#105,873
of 233,604 outputs
Outputs of similar age from BMC Neurology
#25
of 56 outputs
Altmetric has tracked 11,428,083 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,348 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,604 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.