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Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients

Overview of attention for article published in Pharmacogenomics Journal, May 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

twitter
4 tweeters

Citations

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9 Dimensions

Readers on

mendeley
30 Mendeley
citeulike
2 CiteULike
Title
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients
Published in
Pharmacogenomics Journal, May 2018
DOI 10.1038/s41397-018-0025-5
Pubmed ID
Authors

John C. Taylor, Tim Bongartz, Jonathan Massey, Borbala Mifsud, Athina Spiliopoulou, Ian C. Scott, Jianmei Wang, Michael Morgan, Darren Plant, Marco Colombo, Peter Orchard, Sarah Twigg, Iain B. McInnes, Duncan Porter, Jane E. Freeston, Jackie L. Nam, Heather J. Cordell, John D. Isaacs, Jenna L. Strathdee, Donna Arnett, Maria J. H. de Hair, Paul P. Tak, Stella Aslibekyan, Ronald F. van Vollenhoven, Leonid Padyukov, S. Louis Bridges, Costantino Pitzalis, Andrew P. Cope, Suzanne M. M. Verstappen, Paul Emery, Michael R. Barnes, Felix Agakov, Paul McKeigue, Taisei Mushiroda, Michiaki Kubo, Richard Weinshilboum, Anne Barton, Ann W. Morgan, Jennifer H. Barrett

Abstract

Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA), but many patients do not respond adequately. In order to identify genetic predictors of response, we have combined data from two consortia to carry out a genome-wide study of response to MTX in 1424 early RA patients of European ancestry. Clinical endpoints were change from baseline to 6 months after starting treatment in swollen 28-joint count, tender 28-joint count, C-reactive protein and the overall 3-component disease activity score (DAS28). No single nucleotide polymorphism (SNP) reached genome-wide statistical significance for any outcome measure. The strongest evidence for association was with rs168201 in NRG3 (p = 10-7 for change in DAS28). Some support was also seen for association with ZMIZ1, previously highlighted in a study of response to MTX in juvenile idiopathic arthritis. Follow-up in two smaller cohorts of 429 and 177 RA patients did not support these findings, although these cohorts were more heterogeneous.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 37%
Student > Ph. D. Student 4 13%
Professor 3 10%
Student > Postgraduate 2 7%
Student > Master 2 7%
Other 8 27%
Readers by discipline Count As %
Medicine and Dentistry 9 30%
Unspecified 7 23%
Biochemistry, Genetics and Molecular Biology 4 13%
Immunology and Microbiology 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Other 5 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2018.
All research outputs
#7,032,697
of 13,093,005 outputs
Outputs from Pharmacogenomics Journal
#357
of 651 outputs
Outputs of similar age
#121,881
of 270,944 outputs
Outputs of similar age from Pharmacogenomics Journal
#10
of 29 outputs
Altmetric has tracked 13,093,005 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 651 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,944 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.