Title |
The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: A randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults
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Published in |
Nutrition Journal, October 2011
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DOI | 10.1186/1475-2891-10-117 |
Pubmed ID | |
Authors |
Vanessa Danthiir, Nicholas R Burns, Ted Nettelbeck, Carlene Wilson, Gary Wittert |
Abstract |
Some studies have suggested an association between omega-3 long-chain polyunsaturated fatty acids (n-3 LC PUFAs) and better cognitive outcomes in older adults. To date, only two randomised, controlled trials have assessed the effect of n-3 LC PUFA supplementation on cognitive function in older cognitively healthy populations. Of these trials only one found a benefit, in the subgroup carrying the ApoE-ε4 allele. The benefits of n-3 LC PUFA supplementation on cognitive function in older normal populations thus still remain unclear. The main objective of the current study was to provide a comprehensive assessment of the potential of n-3 LC PUFAs to slow cognitive decline in normal elderly people, and included ApoE-ε4 allele carriage as a potential moderating factor. The detailed methodology of the trial is reported herein. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | <1% |
United States | 2 | <1% |
Spain | 1 | <1% |
Canada | 1 | <1% |
Unknown | 263 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 52 | 19% |
Student > Bachelor | 43 | 16% |
Researcher | 31 | 12% |
Student > Ph. D. Student | 25 | 9% |
Student > Doctoral Student | 14 | 5% |
Other | 47 | 17% |
Unknown | 57 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 66 | 25% |
Psychology | 38 | 14% |
Agricultural and Biological Sciences | 27 | 10% |
Nursing and Health Professions | 24 | 9% |
Biochemistry, Genetics and Molecular Biology | 11 | 4% |
Other | 33 | 12% |
Unknown | 70 | 26% |