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Genetic diversity of Plasmodium vivax in clinical isolates from Bangladesh

Overview of attention for article published in Malaria Journal, July 2015
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  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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Title
Genetic diversity of Plasmodium vivax in clinical isolates from Bangladesh
Published in
Malaria Journal, July 2015
DOI 10.1186/s12936-015-0790-4
Pubmed ID
Authors

Mohammad Golam Kibria, Rubayet Elahi, Abu Naser Mohon, Wasif A Khan, Rashidul Haque, Mohammad Shafiul Alam

Abstract

Plasmodium vivax is the second most prevalent human malaria parasite in Bangladesh; however, there are no data of its genetic diversity. Several molecular markers are available where Pvcsp, Pvmsp 1 and Pvmsp 3α are most commonly used for P. vivax genotyping studies. The aim of the study was to investigate the population structure of P. vivax in Bangladesh. A total of 102 P. vivax-positive blood samples were collected from different malaria-endemic areas in Bangladesh and subsequently analysed for those three genotyping markers. Nested PCR was performed for diagnosis and genotyping analysis followed by PCR-RFLP to detect genetic diversity using Pvcsp, Pvmsp 1 and Pvmsp 3α markers. Analysis of Pvcsp showed that the VK210 repeat type was highly prevalent (64.7%, 66/102) compared to VK247 (35.3%, 36/102), although the prevalence of VK247 was higher than other Southeast Asian countries. Analysis of these three genes revealed a diverse, circulating population of P. vivax where a total of ten, 56 and 35 distinct genotypes were detected for Pvcsp, Pvmsp 1 and Pvmsp 3α, respectively. This genotyping observation of P. vivax is the first report from Bangladesh and will provide valuable information for establishing the genotyping methods and circulating genetic variants of these three markers available in Bangladesh.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 17%
Student > Bachelor 7 15%
Student > Master 7 15%
Student > Ph. D. Student 7 15%
Lecturer 2 4%
Other 5 10%
Unknown 12 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 17%
Agricultural and Biological Sciences 8 17%
Immunology and Microbiology 6 13%
Medicine and Dentistry 4 8%
Computer Science 2 4%
Other 5 10%
Unknown 15 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2015.
All research outputs
#6,421,635
of 22,816,807 outputs
Outputs from Malaria Journal
#1,855
of 5,563 outputs
Outputs of similar age
#75,044
of 262,931 outputs
Outputs of similar age from Malaria Journal
#43
of 113 outputs
Altmetric has tracked 22,816,807 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 5,563 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,931 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 113 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.