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Cadmium: From Toxicity to Essentiality

Overview of attention for book
Attention for Chapter 15: Cadmium and cancer.
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 114)
  • High Attention Score compared to outputs of the same age (96th percentile)

Mentioned by

news
1 news outlet
twitter
24 tweeters
facebook
3 Facebook pages
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
50 Dimensions

Readers on

mendeley
43 Mendeley
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Chapter title
Cadmium and cancer.
Chapter number 15
Book title
Cadmium: From Toxicity to Essentiality
Published in
Metal ions in life sciences, January 2013
DOI 10.1007/978-94-007-5179-8_15
Pubmed ID
Book ISBNs
978-9-40-075178-1, 978-9-40-075179-8
Authors

Andrea Hartwig, Hartwig, Andrea

Abstract

Cadmium is an established human and animal carcinogen. Most evidence is available for elevated risk for lung cancer after occupational exposure; however, associations between cadmium exposure and tumors at other locations including kidney, breast, and prostate may be relevant as well. Furthermore, enhanced cancer risk may not be restricted to comparatively high occupational exposure, but may also occur via environmental exposure, for example in areas in close proximity to zinc smelters. The underlying mechanisms are still a matter of manifold research activities. While direct interactions with DNA appear to be of minor importance, elevated levels of reactive oxygen species (ROS) have been detected in diverse experimental systems, presumably due to an inactivation of detoxifying enzymes. Also, the interference with proteins involved in the cellular response to DNA damage, the deregulation of cell growth as well as resistance to apoptosis appears to be involved in cadmium-induced carcinogenicity. Within this context, cadmium has been shown to disturb nucleotide excision repair, base excision repair, and mismatch repair. Particularly sensitive targets appear to be proteins with zinc-binding structures, present in DNA repair proteins such as XPA, PARP-1 as well as in the tumor suppressor protein p53. Whether or not these interactions are due to displacement of zinc or due to reactions with thiol groups involved in zinc complexation or in other critical positions under realistic exposure conditions remains to be elucidated. Further potential mechanisms relate to the interference with cellular redox regulation, either by enhanced generation of ROS or by reaction with thiol groups involved in the regulation of signaling pathways. Particularly the combination of these multiple mechanisms may give rise to a high degree of genomic instability evident in cadmium-adapted cells, relevant not only for tumor initiation, but also for later steps in tumor development.

Twitter Demographics

The data shown below were collected from the profiles of 24 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Lebanon 1 2%
Unknown 42 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 26%
Student > Bachelor 6 14%
Student > Ph. D. Student 6 14%
Student > Master 5 12%
Student > Doctoral Student 3 7%
Other 9 21%
Unknown 3 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 28%
Agricultural and Biological Sciences 8 19%
Medicine and Dentistry 6 14%
Environmental Science 4 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 7%
Other 4 9%
Unknown 6 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2019.
All research outputs
#589,264
of 14,995,644 outputs
Outputs from Metal ions in life sciences
#5
of 114 outputs
Outputs of similar age
#10,176
of 259,584 outputs
Outputs of similar age from Metal ions in life sciences
#1
of 4 outputs
Altmetric has tracked 14,995,644 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 114 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,584 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them