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Cadmium: From Toxicity to Essentiality

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Attention for Chapter 5: Imaging and Sensing of Cadmium in Cells
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Chapter title
Imaging and Sensing of Cadmium in Cells
Chapter number 5
Book title
Cadmium: From Toxicity to Essentiality
Published in
Metal ions in life sciences, February 2016
DOI 10.1007/978-94-007-5179-8_5
Pubmed ID
Book ISBNs
978-9-40-075178-1, 978-9-40-075179-8

Masayasu Taki


Cadmium is one of the highly toxic transition metals for human beings and is known as a human carcinogen. Once humans are exposed to Cd(2+) on a chronic basis, Cd(2+) primarily accumulates in the liver and kidney where it forms complexes with small peptides and proteins via sulfhydryl groups. Complexed Cd(2+) or the ionic Cd(2+) is then taken up by target cells and tissues and exerts the toxicity. However, the question of how non-essential Cd(2+) crosses the cell membranes remains unanswered. Furthermore, the molecular mechanism of Cd(2+)-induced physiological signaling disruption in cells is still not fully elucidated. Investigations of Cd(2+) uptake kinetics, distributions, and concentrations in cells require chemical tools for its detection. Because of the easy use and high spatiotemporal resolution, optical imaging using fluorescence microscopy is a well-suited method for monitoring Cd(2+) in biological samples. This chapter summarizes design principles of small molecule fluorescent sensors for Cd(2+) detection in aqueous solution and their photophysical and metal-binding properties. Also the applications of probes for fluorescence imaging of Cd(2+) in a variety of cell types are demonstrated.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 27%
Student > Bachelor 3 14%
Student > Ph. D. Student 3 14%
Professor > Associate Professor 2 9%
Researcher 2 9%
Other 1 5%
Unknown 5 23%
Readers by discipline Count As %
Chemistry 6 27%
Agricultural and Biological Sciences 5 23%
Physics and Astronomy 1 5%
Economics, Econometrics and Finance 1 5%
Earth and Planetary Sciences 1 5%
Other 3 14%
Unknown 5 23%