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Cadmium: From Toxicity to Essentiality

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Attention for Chapter 5: Imaging and Sensing of Cadmium in Cells
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Chapter title
Imaging and Sensing of Cadmium in Cells
Chapter number 5
Book title
Cadmium: From Toxicity to Essentiality
Published in
Metal ions in life sciences, February 2016
DOI 10.1007/978-94-007-5179-8_5
Pubmed ID
Book ISBNs
978-9-40-075178-1, 978-9-40-075179-8
Authors

Masayasu Taki

Abstract

Cadmium is one of the highly toxic transition metals for human beings and is known as a human carcinogen. Once humans are exposed to Cd(2+) on a chronic basis, Cd(2+) primarily accumulates in the liver and kidney where it forms complexes with small peptides and proteins via sulfhydryl groups. Complexed Cd(2+) or the ionic Cd(2+) is then taken up by target cells and tissues and exerts the toxicity. However, the question of how non-essential Cd(2+) crosses the cell membranes remains unanswered. Furthermore, the molecular mechanism of Cd(2+)-induced physiological signaling disruption in cells is still not fully elucidated. Investigations of Cd(2+) uptake kinetics, distributions, and concentrations in cells require chemical tools for its detection. Because of the easy use and high spatiotemporal resolution, optical imaging using fluorescence microscopy is a well-suited method for monitoring Cd(2+) in biological samples. This chapter summarizes design principles of small molecule fluorescent sensors for Cd(2+) detection in aqueous solution and their photophysical and metal-binding properties. Also the applications of probes for fluorescence imaging of Cd(2+) in a variety of cell types are demonstrated.

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 1 13%
Student > Bachelor 1 13%
Other 1 13%
Student > Master 1 13%
Unknown 4 50%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 25%
Physics and Astronomy 1 13%
Social Sciences 1 13%
Chemistry 1 13%
Unknown 3 38%