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Auditory Cortical Plasticity Drives Training-Induced Cognitive Changes in Schizophrenia

Overview of attention for article published in Schizophrenia Bulletin, July 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

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9 tweeters
facebook
2 Facebook pages

Citations

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37 Dimensions

Readers on

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100 Mendeley
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Title
Auditory Cortical Plasticity Drives Training-Induced Cognitive Changes in Schizophrenia
Published in
Schizophrenia Bulletin, July 2015
DOI 10.1093/schbul/sbv087
Pubmed ID
Authors

Corby L. Dale, Ethan G. Brown, Melissa Fisher, Alexander B. Herman, Anne F. Dowling, Leighton B. Hinkley, Karuna Subramaniam, Srikantan S. Nagarajan, Sophia Vinogradov

Abstract

Schizophrenia is characterized by dysfunction in basic auditory processing, as well as higher-order operations of verbal learning and executive functions. We investigated whether targeted cognitive training of auditory processing improves neural responses to speech stimuli, and how these changes relate to higher-order cognitive functions. Patients with schizophrenia performed an auditory syllable identification task during magnetoencephalography before and after 50 hours of either targeted cognitive training or a computer games control. Healthy comparison subjects were assessed at baseline and after a 10 week no-contact interval. Prior to training, patients (N = 34) showed reduced M100 response in primary auditory cortex relative to healthy participants (N = 13). At reassessment, only the targeted cognitive training patient group (N = 18) exhibited increased M100 responses. Additionally, this group showed increased induced high gamma band activity within left dorsolateral prefrontal cortex immediately after stimulus presentation, and later in bilateral temporal cortices. Training-related changes in neural activity correlated with changes in executive function scores but not verbal learning and memory. These data suggest that computerized cognitive training that targets auditory and verbal learning operations enhances both sensory responses in auditory cortex as well as engagement of prefrontal regions, as indexed during an auditory processing task with low demands on working memory. This neural circuit enhancement is in turn associated with better executive function but not verbal memory.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Spain 1 1%
South Africa 1 1%
Unknown 96 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 18%
Student > Ph. D. Student 16 16%
Researcher 13 13%
Student > Bachelor 9 9%
Student > Doctoral Student 9 9%
Other 23 23%
Unknown 12 12%
Readers by discipline Count As %
Psychology 24 24%
Neuroscience 21 21%
Medicine and Dentistry 13 13%
Nursing and Health Professions 5 5%
Agricultural and Biological Sciences 5 5%
Other 10 10%
Unknown 22 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 September 2016.
All research outputs
#2,745,698
of 14,535,828 outputs
Outputs from Schizophrenia Bulletin
#846
of 2,412 outputs
Outputs of similar age
#48,526
of 231,907 outputs
Outputs of similar age from Schizophrenia Bulletin
#16
of 46 outputs
Altmetric has tracked 14,535,828 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,412 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,907 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.