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Mendeley readers
Attention Score in Context
| Title |
The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis
|
|---|---|
| Published in |
Journal of Rheumatology, December 2008
|
| DOI | 10.3899/jrheum.080346 |
| Pubmed ID | |
| Authors |
Massoud Daheshia, Jian Q Yao |
| Abstract |
Osteoarthritis (OA) is a major disabling disease and is ranked as a major cause of chronic pain in adults. The pathology of the illness is characterized by a loss of articular cartilage leading to narrowing of joint space, increased joint friction, potential structural remodeling, persistent pain, and functional impairment. The proinflammatory cytokine interleukin 1beta (IL-1beta) has several chemical and bioactive characteristics allowing this catabolic protein to be involved in initiation and progression of OA. We review the current understanding of the pathogenesis of OA, and how upregulation of IL-1beta initiates a cascade of intracellular events that can culminate in activation of proteinases, creation of a pro-destructive articular milieu, suppression of anabolic pathways, and a decrease in the synthesis of cartilage extracellular matrix. Therapeutic approaches to block the action of IL-1beta and overcome its signal transduction to curtail disease progression are discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 156 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 21% |
| Researcher | 19 | 12% |
| Student > Bachelor | 19 | 12% |
| Student > Master | 13 | 8% |
| Student > Doctoral Student | 8 | 5% |
| Other | 28 | 18% |
| Unknown | 39 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 18% |
| Agricultural and Biological Sciences | 27 | 17% |
| Medicine and Dentistry | 25 | 16% |
| Engineering | 12 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 16 | 10% |
| Unknown | 45 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2023.
All research outputs
#5,340,533
of 25,377,790 outputs
Outputs from Journal of Rheumatology
#1,140
of 3,951 outputs
Outputs of similar age
#27,607
of 179,625 outputs
Outputs of similar age from Journal of Rheumatology
#6
of 22 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,951 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,625 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.