Title |
An in silico approach combined with in vivo experiments enables the identification of a new protein whose overexpression can compensate for specific respiratory defects in Saccharomyces cerevisiae
|
---|---|
Published in |
BMC Systems Biology, October 2011
|
DOI | 10.1186/1752-0509-5-173 |
Pubmed ID | |
Authors |
Annie Glatigny, Lise Mathieu, Christopher J Herbert, Geneviève Dujardin, Brigitte Meunier, Marie-Hélène Mucchielli-Giorgi |
Abstract |
The mitochondrial inner membrane contains five large complexes that are essential for oxidative phosphorylation. Although the structure and the catalytic mechanisms of the respiratory complexes have been progressively established, their biogenesis is far from being fully understood. Very few complex III assembly factors have been identified so far. It is probable that more factors are needed for the assembly of a functional complex, but that the genetic approaches used to date have not been able to identify them. We have developed a systems biology approach to identify new factors controlling complex III biogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Poland | 1 | 4% |
France | 1 | 4% |
Germany | 1 | 4% |
Unknown | 20 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 30% |
Student > Ph. D. Student | 5 | 22% |
Student > Bachelor | 2 | 9% |
Professor > Associate Professor | 2 | 9% |
Lecturer > Senior Lecturer | 1 | 4% |
Other | 3 | 13% |
Unknown | 3 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 48% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Computer Science | 2 | 9% |
Engineering | 2 | 9% |
Mathematics | 1 | 4% |
Other | 2 | 9% |
Unknown | 3 | 13% |