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The Ramazzini Institute 13-week study on glyphosate-based herbicides at human-equivalent dose in Sprague Dawley rats: study design and first in-life endpoints evaluation

Overview of attention for article published in Environmental Health, May 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)

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37 tweeters
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1 Facebook page

Citations

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18 Dimensions

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60 Mendeley
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Title
The Ramazzini Institute 13-week study on glyphosate-based herbicides at human-equivalent dose in Sprague Dawley rats: study design and first in-life endpoints evaluation
Published in
Environmental Health, May 2018
DOI 10.1186/s12940-018-0393-y
Pubmed ID
Authors

Simona Panzacchi, Daniele Mandrioli, Fabiana Manservisi, Luciano Bua, Laura Falcioni, Marcella Spinaci, Giovanna Galeati, Giovanni Dinelli, Rossella Miglio, Alberto Mantovani, Stefano Lorenzetti, Jianzhong Hu, Jia Chen, Melissa J. Perry, Philip J. Landrigan, Fiorella Belpoggi

Abstract

Glyphosate-based herbicides (GBHs) are the most widely used pesticides worldwide, and glyphosate is the active ingredient of such herbicides, including the formulation known as Roundup. The massive and increasing use of GBHs results in not only the global burden of occupational exposures, but also increased exposure to the general population. The current pilot study represents the first phase of a long-term investigation of GBHs that we are conducting over the next 5 years. In this paper, we present the study design, the first evaluation of in vivo parameters and the determination of glyphosate and its major metabolite aminomethylphosphonic acid (AMPA) in urine. We exposed Sprague-Dawley (SD) rats orally via drinking water to a dose of glyphosate equivalent to the United States Acceptable Daily Intake (US ADI) of 1.75 mg/kg bw/day, defined as the chronic Reference Dose (cRfD) determined by the US EPA, starting from prenatal life, i.e. gestational day (GD) 6 of their mothers. One cohort was continuously dosed until sexual maturity (6-week cohort) and another cohort was continuously dosed until adulthood (13-week cohort). Here we present data on general toxicity and urinary concentrations of glyphosate and its major metabolite AMPA. Survival, body weight, food and water consumption of the animals were not affected by the treatment with either glyphosate or Roundup. The concentration of both glyphosate and AMPA detected in the urine of SD rats treated with glyphosate were comparable to that observed in animals treated with Roundup, with an increase in relation to the duration of treatment. The majority of glyphosate was excreted unchanged. Urinary levels of the parent compound, glyphosate, were around 100-fold higher than the level of its metabolite, AMPA. Glyphosate concentrations in urine showed that most part of the administered dose was excreted as unchanged parent compound upon glyphosate and Roundup exposure, with an increasing pattern of glyphosate excreted in urine in relation to the duration of treatment. The adjuvants and the other substances present in Roundup did not seem to exert a major effect on the absorption and excretion of glyphosate. Our results demonstrate that urinary glyphosate is a more relevant marker of exposure than AMPA in the rodent model.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 23%
Researcher 10 17%
Student > Bachelor 7 12%
Student > Ph. D. Student 4 7%
Student > Postgraduate 3 5%
Other 8 13%
Unknown 14 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 18%
Environmental Science 7 12%
Medicine and Dentistry 6 10%
Biochemistry, Genetics and Molecular Biology 6 10%
Chemistry 3 5%
Other 11 18%
Unknown 16 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2020.
All research outputs
#929,574
of 16,650,161 outputs
Outputs from Environmental Health
#211
of 1,274 outputs
Outputs of similar age
#27,351
of 284,692 outputs
Outputs of similar age from Environmental Health
#1
of 1 outputs
Altmetric has tracked 16,650,161 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,274 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,692 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them